| Identification | Back Directory | [Name]
HEXAMETHONIUM CHLORIDE | [CAS]
60-25-3 | [Synonyms]
depressin
hexonchloride
hexonechloride
hiohexchloride
esomidchloride
chloor-hexaviet
methiumchloride
bistriumchloride
hestriumchloride
hexametonchloride
hexamethioniumchloride
HEXAMETHONIUM CHLORIDE
HEXAMETHONIUM DICHLORIDE
HexaMethoniuM Chloride
HEXANE-1,6-BIS[TRIMETHYLAMMONIUM CHLORIDE]
A,W-BIS(TRIMETHYLAMMONIUM)HEXANE DICHLORIDE
HEXAMETHYLENEBIS[TRIMETHYLAMMONIUM CHLORIDE]
hexamethylenebis(trimethyl-ammoniudichloride
Hexamethylenebis(trimethylaminium)·dichloride
ALPHA OMEGA-BIS(TRIMETHYLAMMONIUM)HEXANE DICHLORIDE
6-hexanediaminium,n,n,n,n’,n’,n’-hexamethyl-dichloride
n,n,n,n',n',n'-hexamethyl-1,6-hexanediammonium dichloride
N,N,N,N',N',N'-Hexamethyl-1,6-hexanediaminium dichloride
N1,N1,N1,N6,N6,N6-hexaMethylhexane-1,6-diaMiniuM chloride
N,N,N,N',N',N'-Hexamethylhexamethylenediammonium dichloride
Hexamethylenebis(trimethylammonium Chloride)
N,N,N,N',N',N'-Hexamethyl-1,6-hexanediammonium Dichloride
Hexane-1,6-bis(trimethylammonium Chloride)
Hexamethonium dichloride, N,N,N,Nμ,Nμ,Nμ-Hexamethyl-1,6-hexanediaminium dichloride, N,N,N,Nμ,Nμ,Nμ-Hexamethylhexamethylenediammonium dichloride | [EINECS(EC#)]
200-465-1 | [Molecular Formula]
C12H30Cl2N2 | [MDL Number]
MFCD00031563 | [MOL File]
60-25-3.mol | [Molecular Weight]
273.29 |
| Chemical Properties | Back Directory | [Appearance]
White, crystalline, hygroscopic powder; faint odor. Very
soluble in water; soluble in alcohol, methanol,
and n-propanol; insoluble in chloroform and ether.
Available commercially as unhydrated form or as
dihydrate. | [Melting point ]
292°C(dec.)(lit.) | [Boiling point ]
423.36°C (rough estimate) | [density ]
1.0558 (rough estimate) | [refractive index ]
1.6400 (estimate) | [solubility ]
H2O: soluble
| [form ]
solid (hygroscopic)
| [color ]
white
| [Water Solubility ]
almost transparency | [BRN ]
3714806 | [Uses]
Medicine (antihypertensive). | [CAS DataBase Reference]
60-25-3 | [EPA Substance Registry System]
1,6-Hexanediaminium, N,N,N,N',N',N'-hexamethyl-, dichloride (60-25-3) |
| Hazard Information | Back Directory | [Chemical Properties]
White, crystalline, hygroscopic powder; faint odor. Very
soluble in water; soluble in alcohol, methanol,
and n-propanol; insoluble in chloroform and ether.
Available commercially as unhydrated form or as
dihydrate. | [General Description]
Nicotinic acetylcholine receptor (nAChR) forms a ligand-gated ion channel made up of four different subunits. Each subunit contains an extracellular amino-terminal domain (hydrophilic) and carboxylic terminal domain and four transmembrane domains. nAChR is an allosteric and transmembrane protein localized to the neuromuscular junction. | [Biochem/physiol Actions]
Hexamethonium chloride preferentially blocks nicotinic receptors at autonomic ganglia, crosses blood-brain barrier only at high doses. Nicotinic acetylcholine receptor (nAChR) is responsible for cognitive functions. Blocking this receptor results in cognitive impairment. nAChR antagonist is used to study the effect of loss of receptor function. Hexamethonium has a peripheral action over blocking the nAChR. |
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