| Identification | Back Directory | [Name]
ALPHA-ENDORPHIN | [CAS]
59004-96-5 | [Synonyms]
LPH(61-76)
a-Endorphin
α-Endorphin
ALPHA-ENDORPHIN
YGGFMTSEKSQTPLVT
A-ENDORPHIN HUMAN
α-endorphin human
α-Endorphin human
ENDORPHIN, ALPHA-
β-Lipotropin 61-76
β-Endorphin (1-16)
β-Endorphin (1-16)
ALPHA-ENDORPHIN HUMAN
BETA-ENDORPHIN (1-16)
alpha-Endorphin (pig)
alpha-Endorphin (sheep)
Porcine alpha-endorphin
BETA-LIPOTROPIN (61-76)
alpha-Endorphin acetate
ALPHA-ENDORPHIN USP/EP/BP
alpha-Endorphin (porcine)
β-Lipotropin(61-76), human
synthetic, β-Lipotropin 61-76
α-Endorphin human, ≥97% (HPLC)
BETA-LIPOTROPIN (59-74) (HUMAN)
ALPHA-ENDORPHIN HUMAN SYNTHETIC
β-lipotropin (61-76), human, synthetic
alpha-Endorphin acetate (59004-96-5 Free base)
b-Endorphin (1-16), b-Lipotropin (59-74) (huMan)
-Endorphin (human, mouse, rat, porcine, bovine, ovine)
TYR-GLY-GLY-PHE-MET-THR-SER-GLU-LYS-SER-GLN-THR-PRO-LEU-VAL-THR
TYR-GLY-GLY-PHE-MET-THR-SER-GLU-LYS-SER-GLN-THR-PRO-LEU-VAL-TYR
H-TYR-GLY-GLY-PHE-MET-THR-SER-GLU-LYS-SER-GLN-THR-PRO-LEU-VAL-THR-OH
TYR-GLY-GLY-PHE-MET-THR-SER-GLU-LYS-SER-GLN-THR-PRO-LEU-VAL-THR: YGGFMTSEKSQTPLVT
TYR-GLY-GLY-PHE-MET-THR-SER-GLU-LYS-SER-GLN-THR-PRO-LEU-VAL-THR-LEU-PHE-LYS-ASN-ALA-ILE-ILE-LYS-ASN-ALA-TYR-LYS-LYS-GLY-GLU
β-Lipotropin (61-76), human, synthetic, β-Lipotropin 61-76, LPH (61-76), Tyr-Gly-Gly-Phe-Met-Thr-Ser-Glu-Lys-Ser-Gln-Thr-Pro-Leu-Val-Thr | [EINECS(EC#)]
262-330-3 | [Molecular Formula]
C77H120N18O26S | [MDL Number]
MFCD00076381 | [MOL File]
59004-96-5.mol | [Molecular Weight]
1745.95 |
| Hazard Information | Back Directory | [Uses]
An opioid peptide and substrate for transglutaminase | [Biological Activity]
endorphins are endogenous opioid peptides that function as neurotransmitters(1). they are produced by the pituitary gland and the hypothalamus in vertebrates during exercise, excitement, pain, consumption of spicy food, love and orgasm, and they resemble the opiates in their abilities to produce analgesia and a feeling of well-being.the term implies a pharmacological activity (analogous to the activity of the corticosteroid category of biochemicals) as opposed to a specific chemical formulation. it consists of two parts: endo- and -orphin; these are short forms of the words endogenous and morphine(2), beta-endorphin (β-endorphin) is released into blood from the pituitary gland and into the spinal cord and brain from hypothalamic neurons. the β-endorphin that is released into the blood cannot enter the brain in large quantities because of the blood–brain barrier, so the physiological importance of the β-endorphin that can be measured in the blood is far from clear. β-endorphin is a cleavage product of pro-opiomelanocortin (pomc), which is also the precursor hormone for adrenocorticotrophic hormone (acth). the behavioural effects of β-endorphin are exerted by its actions in the brain and spinal cord, and it is presumed that the hypothalamic neurons are the major source of β-endorphin at these sites. in situations where the level of acth is increased (e.g., cushing’s syndrome), the level of endorphins also increases slightly(3).figure1 formula of a-endorphinfigure 2 mechanism of endorphin to inhibit lhrh release | [References]
1. Oswald Steward: Functional neuroscience (2000), page 116.2. Goldstein A, Lowery PJ (September 1975). "Effect of the opiate antagonist naloxone on body temperature in rats". Life Sciences 17 (6): 927–31.3. Simantov R, Snyder S (1976). "Morphine-like peptides in mammalian brain: isolation, structure elucidation, and interactions with the opiate receptor". Proc Natl Acad Sci USA 73 (7): 2515–9. |
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