| Identification | Back Directory | [Name]
2-(4-FLUOROPHENYL)THIOPHENE | [CAS]
58861-48-6 | [Synonyms]
2-(4-FL
AKOS BAR-1344
Canagliflozin INT2
IFLAB-BB F2108-0130
Impurity of caglitazin
Cagliflozin Impurity 14
2-(4-fluorophenyl)thiophen
Canagliflozin intermediate
2-(4-FLUOROPHENYL)THIOPHENE
Canagliflozin Intermediate I
Thiophene, 2-(4-fluorophenyl)-
2-(4-Fluorophenyl)thiophene>
Canagliflozin Related Impurity 14
2-(4-FLUOROPHENYL)THIOPHENE 58861-48-6
2-(4-FLUOROPHENYL)THIOPHENE ISO 9001：2015 REACH | [EINECS(EC#)]
611-756-1 | [Molecular Formula]
C10H7FS | [MDL Number]
MFCD06802535 | [MOL File]
58861-48-6.mol | [Molecular Weight]
178.23 |
| Chemical Properties | Back Directory | [Melting point ]
51.0 to 55.0 °C | [Boiling point ]
252.3±15.0 °C(Predicted) | [density ]
1.200±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,2-8°C | [solubility ]
soluble in Methanol | [form ]
powder to crystal | [color ]
Light orange to Yellow to Green | [InChI]
InChI=1S/C10H7FS/c11-9-5-3-8(4-6-9)10-2-1-7-12-10/h1-7H | [InChIKey]
PURJRGMZIKXDMW-UHFFFAOYSA-N | [SMILES]
C1(C2=CC=C(F)C=C2)SC=CC=1 | [CAS DataBase Reference]
58861-48-6 |
| Hazard Information | Back Directory | [Chemical Properties]
white solid | [Uses]
2-(4-Fluorophenyl)-thiophene can be used to prepare Canagliflozin (C175190) as sodium-dependent glucose co-transporter 2 (SGLT2) inhibitor for treatment of type 2 diabetes mellitus. | [Synthesis]
4-fluorobenzoic boric acid and 2-bromothiophene, Pd catalyst are added in organic solvent and dissolves, obtain material 3, wherein: 4-fluorine Phenylboric acid molar concentration in organic solvent is 0.5mol/L～2mol/L, and 4-fluorobenzoic boric acid with the mol ratio of 2-bromothiophene is 1:1.0～1:1.5,4-fluorobenzoic boric acid is 1:0.005～1:0.1 with the mol ratio of catalyst；Using material 3 with as material 4 Inorganic base aqueous solution carries out pre-incubation respectively to being 1:1.0～1 according to the mol ratio of 4-fluorobenzoic boric acid Yu alkali after reaction temperature: The mode of 3.0 mixes, and reacts under conditions of 50 ℃～80 ℃, then carries out post processing and obtains 2-(4-fluorophenyl) Thiophene. |
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