| Identification | Back Directory | [Name]
ZYMOSAN A | [CAS]
58856-93-2 | [Synonyms]
ZYMOSAN
ZYMOSAN A
A zymosans
Zymosans A
Zymosan type A
YEAST POLYSACCHARIDES
Zymosan, Pre-activated
anticomplementary factor
Zymosan, Saccharomyces cerevisiae,
Zymosan A fromSaccharomycecerevisiae
ZYMOSAN A FROM SACCHAROMYCES CEREVISAE
zymosan A from saccharomyces cerevisiae
Zymosan A from saccharomyees cerevisiae
Zymosan A from Saccharomyces cerevisiae Vetec(TM) reagent grade | [EINECS(EC#)]
232-725-5 | [Molecular Formula]
n.a. | [MDL Number]
MFCD00082157 |
| Chemical Properties | Back Directory | [RTECS ]
ZI2750000 | [storage temp. ]
2-8°C
| [solubility ]
Chloroform: 100 μg/ml; DMSO: 200 μg/ml; Ethanol: 100 μg/ml | [form ]
Powder | [color ]
off-white to light brown | [biological source]
Saccharomyces cerevisiae |
| Hazard Information | Back Directory | [Uses]
Zymosan A from Saccharomyces cerevisiae has been used:
- as a positive control to determine the activation of complement cascade
- for respiratory burst (RB) assay
- to assess its effects on performance, immunity, heat shock protein and apoptosis related gene expressions of dairy cows under heat stress (HS)
- a stimulating agent in Krebs-Ringer phosphate (KRP) medium
- to induce thermal hyperalgesia in mice
| [Biochem/physiol Actions]
Zymosan is prepared from yeast cell wall and consists of protein-carbohydrate complexes. It is used to induce experimental sterile inflammation. In macrophages, zymosan-induced responses include the induction of proinflammatory cytokines, arachidonate mobilization, protein phosphorylation, and inositol phosphate formation. Zymosan A also raises cyclin D2 levels suggesting a role for the latter in macrophage activation besides proliferation. It potentiates acute liver damage after galactosamine injection suggesting that certain types of nonparenchymal cells other than Kupffer cells are involved in zymosan action. Zymosan A, a 13 beta glucan contributes to the development of organic dust-induced respiratory disease. |
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