| Identification | Back Directory | [Name]
Gomisin A | [CAS]
58546-54-6 | [Synonyms]
D01752
TJN-101
GOMISIN A
Besigomsin
BESIGOMISIN
wuweizichunb
SCHISANDROL B
SCHIZANDROL B
wuweizialcoholb
Grifola frondsa
Gomisin A Standard
Besigomsin (jan/inn)
Gomisin A/Schisandrin
Schizandrol B，Gomisin A
Schisandrol B (Gomisin-A
Grifola frondosa (Dicks.) Gray
2,3,13-tetramethoxy-l-stereoisomer
Schizandrol B, froM Schisandra chinensis
Schizandrol B, 98%, from Schisandra chinensis (Turcz.) Baill.
benzo(3,4)cycloocta(1,2-f)(1,3)benzodioxol-6-ol,5,6,7,8-tetrahydro-6,7-dimethy
(6S,7S,13aR)-5,6,7,8-Tetrahydro-1,2,3,13-tetramethoxy-6,7-dimethylbenzo[3,4]cycloocta[1,2-f][1,3]benzodioxol
(6S,7S)-5,6,7,8-Tetrahydro-1,2,3,13-tetramethoxy-6β,7β-dimethylbenzo[3,4]cycloocta[1,2-f][1,3]benzodioxol-6α-ol
Benzo[3,4]cycloocta[1,2-f][1,3]benzodioxol-6-ol, 5,6,7,8-tetrahydro-1,2,3,13-tetramethoxy-6,7-dimethyl-, (6S,7S,13aR)-
(6S,7S)-1,2,3,13-Tetramethoxy-6,7-dimethyl-5,6,7,8-tetrahydrobenzo[3',4']cycloocta[1',2':4,5]benzo[1,2-d][1,3]dioxol-6-ol | [Molecular Formula]
C23H28O7 | [MDL Number]
MFCD01941645 | [MOL File]
58546-54-6.mol | [Molecular Weight]
416.46 |
| Chemical Properties | Back Directory | [Melting point ]
88.5°C | [Boiling point ]
454.79°C (rough estimate) | [density ]
1.1772 (rough estimate) | [refractive index ]
1.5300 (estimate) | [storage temp. ]
Sealed in dry,Store in freezer, under -20°C | [solubility ]
DMSO : 50 mg/mL (120.06 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble) | [form ]
powder to crystal | [pka]
14.58±0.40(Predicted) | [color ]
White to Light yellow | [LogP]
4.770 (est) |
| Hazard Information | Back Directory | [Description]
Schisandrol B is a lignan originally isolated from S. chinensis that has hepatoprotective activity.1 It increases the expression of pregnane X receptor (PXR) target genes involved in bile acid metabolism, including Cyp3a11, Ugt1a1, Oatp2, and Mrp3 in mouse liver and CYP3A4, UGT1A1, and OATP2 in HEK293T cells.2 It also protects against lithocholic acid-induced hepatic necrosis and intrahepatic cholestasis in wild-type, but not Pxr-null, mice and decreases mortality in a mouse model of cholestasis when administered at a dose of 100 mg/kg twice per day. It also promotes liver regeneration following partial hepatectomy and protects against hepatotoxicity induced by acetaminophen (Item No. 10024).3,4 | [Chemical Properties]
White powder | [Uses]
Schizandrol B exhibits potent protective effects of on ET-1-induced dysfunctional human-induced pluripotent stem cell-derived cardiomyocytes (hiPS-CMs). Anti-cholestasis effect. |
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