| Identification | Back Directory | [Name]
5-Carboxy-8-hydroxyquinoline | [CAS]
5852-78-8 | [Synonyms]
IOX1
CS-1524
IOX-1;IOX 1
IOX 1, >=98%
5-Carboxy-8-hydroxyquinoline
JMJD2 Inhibitor, 5-carboxy-8HQ
8-Hydroxyquinoline-5-carboxylic Acid
8-hydroxy-5-Quinolinecarboxylic acid
5-Quinolinecarboxylic acid, 8-hydroxy-
5-Carboxy-8-hydroxyquinoline USP/EP/BP
8-Hydroxyquinoline-5-carboxylic acid 95%
JMJD2 Inhibitor, 5-carboxy-8HQ - CAS 5852-78-8 - Calbiochem | [Molecular Formula]
C10H7NO3 | [MDL Number]
MFCD18417145 | [MOL File]
5852-78-8.mol | [Molecular Weight]
189.17 |
| Chemical Properties | Back Directory | [Melting point ]
301 °C (decomp) | [Boiling point ]
464.5±30.0 °C(Predicted) | [density ]
1.480±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: soluble10mg/mL, clear | [form ]
powder | [pka]
1.82±0.10(Predicted) | [color ]
white to brown | [Stability:]
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. | [InChIKey]
JGRPKOGHYBAVMW-UHFFFAOYSA-N |
| Hazard Information | Back Directory | [Description]
IOX 1 (5852-78-8) inhibits the JMJD family of 2-oxoglutarate-dependent histone demethylases. IC50 = 0.12, 0.07, 0.2, 0.3, 0.6, and 1 μM for JMJD3, JMJD1A, JMJD2A, JMJD2E, JMJD2C and UTX respectively.1?A broad spectrum 2-oxoglutarate oxygenase inhibitor, IOX 1 may be used to study hypoxic signaling.1?Cell permeable | [Uses]
5-Carboxy-8-hydroxyquinoline is an inhibitor of KDM2/7 histone demethylase. 5-Carboxy-8-hydroxyquinoline has also shown potential to be used as a regulator of plant growth.
| [Definition]
ChEBI:8-hydroxy-5-quinolinecarboxylic acid is a member of quinolines. | [Biochem/physiol Actions]
IOX1 (5-Carboxy-8-hydroxyquinoline) is a broad spectrum inhibitor of 2-oxoglutarate (2OG) oxygenases, including Jumonji C domain (JmjC) demethylases. It is useful for the study of histone demethylation and hypoxic sensing and results in translocation of active site iron on the 2OG oxygenases. For full characterization details, please visit the IOX1 probe summary on the Structural Genomics Consortium (SGC) website.To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc | [storage]
Store at -20°C | [References]
1) King et al. (2010), Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitors; PLoS One, 5 e15535 |
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