成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

ChemicalBook--->CAS DataBase List--->58-19-5

58-19-5

58-19-5 Structure

58-19-5 Structure
IdentificationBack Directory
[Name]

Dromostanolone
[CAS]

58-19-5
[Synonyms]

Metholone
Medrotestron
Dromostanolone
Drostanolone/Dromostanolone
Dihydro-2α-Methyltestosterone
2α-Methyl-5α-dihydrotestosterone
2α-Methyl-5α-androstan-17β-ol-3-one
2α-Methyl-17β-hydroxyandrostan-3-one
(5α)-2α-Methyl-4,5-dihydrotestosterone
17β-Hydroxy-2α-methyl-5α-androstan-3-one
2α-Methyl-17β-hydroxy-5α-androstan-3-one
(2a,5a,17b)-17-Hydroxy-2-methylandrostan-3-one
(2α,5α,17β)-17-Hydroxy-2-Methylandrostan-3-one
Androstan-3-one,17-hydroxy-2-Methyl-, (2a,5a,17b)-
(2R,5S,8R,9S,10S,13S,14S,17S)-17-hydroxy-2,10,13-trimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-3-one
[EINECS(EC#)]

200-367-9
[Molecular Formula]

C20H32O2
[MDL Number]

MFCD00198322
[MOL File]

58-19-5.mol
[Molecular Weight]

304.47
Chemical PropertiesBack Directory
[Melting point ]

145-147°C
[alpha ]

D +32° (ethanol)
[Boiling point ]

420.3±45.0 °C(Predicted)
[density ]

1.058±0.06 g/cm3(Predicted)
[storage temp. ]

Refrigerator
[solubility ]

Acetonitrile: 1 mg/mL; Ethanol: 1 mg/mL; Methanol: 1 mg/mL
[form ]

A crystalline solid
[pka]

15.09±0.70(Predicted)
[CAS DataBase Reference]

58-19-5
[NIST Chemistry Reference]

Drostanolone(58-19-5)
Hazard InformationBack Directory
[Chemical Properties]

White Solid
[Uses]

Synthetic estrogen antagonist. Antineoplastic. Controlled substance.
[Description]

Drostanolone, also known as Dromostanolone[58-19-5], is an anabolic hormone and a derivative of methyltestosterone. Its action is similar to that of Conviron. Its anabolic effect is 4 times that of methyltestosterone and its androgenic activity is 0.39 times that of the latter. It is clinically used in the treatment of chronic wasting disease, pediatric underdevelopment, old age and frailty, serious illness and postoperative weakness, osteoporosis, aplastic anemia, leukopenia, thrombocytopenia, and hyperlipidemia.
[Originator]

Drolban,Lilly,US,1961
[Definition]

ChEBI: Metholone is a 17beta-hydroxy steroid, an anabolic androgenic steroid and a 3-oxo-5alpha-steroid. It has a role as an anabolic agent and an antineoplastic agent.
[Manufacturing Process]

A suspension of 10 grams of dihydrotestosterone in 500 cc of anhydrous benzene free of thiophene was mixed with10 cc of ethyl formate and 3 grams of sodium hydride and the mixture was stirred for 5 hours under an atmosphere of nitrogen and at a temperature of approximately 25°C. The resulting suspension was filtered, the resulting mixture of the sodium salt of the hydroxymethylene compound and the excess of sodium hydride was washed with benzene and dried. This mixture was slowly added to a vigorously stirred solution of 20 cc of concentrated hydrochloric acid in 500 cc of water, and the stirring was continued for 30 minutes at the end of which the precipitate was collected and well washed with distilled water. After drying in vacuo, there was obtained 9.7 grams of 2-hydroxymethylenedihydrotestosterone.
A mixture of 1 gram of 2-hydroxymethylene-dihydrotestosterone, 10 cc of pyridine and 2 cc of propionic anhydride was allowed to react at room temperature for 16 hours and then poured into water. The resulting suspension was heated for 1 hour on the steam bath to hydrolyze the excess of propionic anhydride, cooled and extracted with methylene dichloride. The extract was consecutively washed with dilute hydrochloric acid, sodium bicarbonate solution and water, dried over anhydrous sodium sulfate and evaporated to dryness under vacuum. There was thus obtained the dipropionate of 2-hydroxymethylenedihydrotestosterone which was treated with hydrogen, in methanol solution.
When the uptake of hydrogen ceased, the catalyst was filtered and the solution was evaporated to dryness under vacuum. The residue was dissolved in a mixture of benzene-hexane, transferred to a chromatographic column with neutral alumina and the product was eluted with mixtures of benzenehexane, gradually increasing the proportion of benzene in the mixture. Crystallization of the eluates from acetone-hexane yielded the propionate of 2α-methyldihydrotestosterone.
[Brand name]

Drolban (Lilly).
[Therapeutic Function]

Cancer chemotherapy
[Synthesis]

Drostanolone is prepared by this “one-pot-reaction”-step the conversion to the 1α-methyl-group is performed simultaneously with the cleavage of the protective group at the 17β-alcohol: 10.60 g Hydroxymethylene-precusor 2-Hydroxymethylene-androstan-17β-((tetrahydro-2H-pyran-2-yl)oxy)-3-one was nearly dissolved in 800 ml ethanol at 55°C. This solution was hydrogenated in a pressure vessel (Parr reactor) with 6.00 g palladium on charcoal (5%) at 4 bar and room temperature for 24 h. The mixture was filtered twice through paper and the corresponding ethanol solution was evaporated, to yield 9.50 g colorless oil, still contains traces of charcoal and ethanol. The crude product was purified by column chromatography on silica gel by using hexane-ethyl acetate (8:2) as an eluent, to afford 5.45 g purified Drostanolone as a colorless solid (69%) . MS (ESI+): m/z = 304.96 (calculated MW: 304.47 g/mol) Rf: 0.35, hexane/ethyl acetate 7:3, visualized by Seebach derivatization reagent. 1 H NMR(300 MHz, DMSO-d6) : δ 4.42 (d, 1 H, OH), 3.42 (m, 1H, HCHOH), 3.32 (s, 1H, CH), 2.37 (t, 1 H, CH), 1.99 (dd, 1 H, ), 1.84 (dd, 1H), 1.78 – 1.84 (m, 1H), 1.72 (m, 1H), 1.61 (m, 1H), 1.22-1.58 (m, 8H), 1.08 – 1.22 (m, 1H), 1.03 (s, 3H, CH3), 0.76-1.01 (m + d, 7H, 2α-CH3 +X), 0.65 – 0.72 (m, 1H), 0.64 (s, 3H, CH3).
[Mode of action]

It can promote protein synthesis and inhibit protein xenobiosis, reduce calcium and phosphorus excretion and alleviate bone marrow suppression, promote growth and development, promote tissue renewal and granulation, and reduce blood cholesterol, and have preventive and antagonistic effects on adrenocorticotropic hormone long-term use of adrenocorticotropic hypoplasia and protein anisotropy.
[References]

[1] SCH?NZER W, DONIKE M. Metabolism of anabolic steroids in man: synthesis and use of reference substances for identification of anabolic steroid metabolites[J]. Analytica Chimica Acta, 1993, 275: 23-48. DOI:10.1016/0003-2670(93)80274-O.
[2] KINTZ P, GHEDDAR L. Evidence of use of drostanolone, an anabolic steroid, at the time the subject committed a murder: Place of hair analysis[J]. Toxicologie Analytique et Clinique, 2021. DOI:10.1016/J.TOXAC.2021.05.002.
[3] LIU Y, LU J, YANG S, et al. New drostanolone metabolites in human urine by liquid chromatography time-of-flight tandem mass spectrometry and their application for doping control[J]. Steroids, 2016, 108: 61-67. DOI:10.1016/j.steroids.2016.01.013.
Raw materials And Preparation ProductsBack Directory
[Raw materials]

Stearic acid-->Sorbitol-->Stanolone-->Propionic anhydride-->Sodium hydride-->Ethyl formate
Safety DataBack Directory
[Hazardous Substances Data]

58-19-5(Hazardous Substances Data)
58-19-5 suppliers list
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: +86-0371-55170693 +86-19937530512 , +86-19937530512
Website: https://www.tianfuchem.com/
Company Name: Hubei xin bonus chemical co. LTD
Tel: 86-13657291602
Website: www.is0513.com/ShowSupplierProductsList1549548/0.htm
Company Name: ANHUI WITOP BIOTECH CO., LTD
Tel: +8615255079626 , +8615255079626
Website: www.is0513.com/showsupplierproductslist418627/0_en.htm
Company Name: Shanghai Likang New Materials Co., Limited
Tel: +86-16631818819 +86-17736933208 , +86-17736933208
Website:
Company Name: Amadis Chemical Company Limited
Tel: 571-89925085
Website: http://www.amadischem.com
Company Name: Hebei Jiangkai Trading Co., Ltd  
Tel: 0086-17197824289,17197824028
Website: www.is0513.com/ShowSupplierProductsList30266/0.htm
Company Name: LGM Pharma  
Tel: 1-(800)-881-8210
Website: www.lgmpharma.com
Company Name: ChemeGen(Shanghai) Biotechnology Co.,Ltd.  
Tel: 18818260767
Website: http://www.chemegen.com
Company Name: Shanghai Saikerui Biotechnology Co. , Ltd.  
Tel: 021-58000709 15900491054
Website: www.scrbio.com/
Company Name: Cayman Chemical Company  
Tel: (800) 364-9897
Website: www.caymanchem.com
Company Name: Pharma Affiliates  
Tel: 172-5066494
Website: http://www.is0513.com/ShowSupplierProductsList694812/0.htm
Company Name: Pharmaffiliates Analytics and Synthetics P. Ltd  
Tel: +91-172-5066494
Website: www.pharmaffiliates.com
Company Name: CLEARSYNTH LABS LTD.  
Tel: +91-22-45045900
Website: www.clearsynth.com
Company Name: Shanghai Hao Zhun Biological Technology Co., Ltd.  
Tel: 15800340161
Website: www.zzsrm.com
Company Name: Alfa Chemistry   
Tel: +1 (201) 478-8534
Website: www.alfa-chemistry.com
Company Name: Toronto Research Chemicals  
Tel: +1 (416) 665-9696
Website: www.trc-canada.com
Company Name: Amfinecom Inc.   
Tel: +1 (804) 861-0001
Website: www.amfinecom.com
Company Name: Altan Corporation  
Tel: 203-283-5157
Website: www.altanbiochemicals.com
Tags:58-19-5 Related Product Information
72-63-9 63-05-8 1914-99-4 481-29-8 999-97-3 112-18-5 872-50-4 521-18-6 521-12-0