| Identification | Back Directory | [Name]
L-Arginine, α-Methyl-4-(2-Methylpropyl)benzeneacetate | [CAS]
57469-82-6 | [Synonyms]
Buprofen Arginine
Ketoprofen Powder
Ibuprofen Arginate
Ibuprofen Impurity Y
Ibuprofen arginine salt
Ibuprofen Arginate >=98% (HPLC)
L-Arginine, α-Methyl-4-(2-Methylpropyl)benzeneacetate
L-Arginine, α-Methyl-4-(2-Methylpropyl)benzeneacetate
(S)-2-Amino-5-guanidinopentanoic acid compound with 2-(4-isobutylphenyl)propanoic acid (1:1) | [EINECS(EC#)]
244-065-5 | [Molecular Formula]
C19H32N4O4 | [MDL Number]
MFCD23701748 | [MOL File]
57469-82-6.mol | [Molecular Weight]
380.482 |
| Hazard Information | Back Directory | [Biological Activity]
Ibuprofen arginate is the more soluble arginate salt form of the nonsteroidal anti-inflammatory drug (NSAID) ibuprofen. Ibuprofen arginate retains the inhibitory potency against COX-2 as ibuprofen and its sodium salthowever only ibuprofen arginate is able to augment cellular NO pathway through codelivery of the NOS substrate arginine. Ibuprofen arginatebut not the sodium salt formis shown to reverse the inhibitory effects of the cardiotoxic hormone asymmetric dimethylarginine (ADMA) and NG-nitro-L-argininemethyl ester (L-NAME) against nitric oxide synthase (eNOS & iNOS) in cultures in vitro (Murine RAW264.7 macrophages and isolated mouse & r at aorta) and effectively prevent L-NAME-induced arterial blood pressure increase in anesthetized rats in vivo (0.5 mg/kg L-NAME; 114.8 μmol/kg ibuprofen arginateequivalent to 20 mg/kg L-Arg via femoral artery cannulation). |
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