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ChemicalBook--->CAS DataBase List--->57226-68-3

57226-68-3

57226-68-3 Structure

57226-68-3 Structure
IdentificationBack Directory
[Name]

NORFLUOXETINE HYDROCHLORIDE
[CAS]

57226-68-3
[Synonyms]

NORFLUOXETINE HCL
Fluoxetine EP Impurity H
NORFLUOXETINE HYDROCHLORIDE
Fluoxetine Impurity 8(EP-H)
Norfluoxetine Hydrochloride Solution, 100ppm
Norfluoxetine hydrochloride (Desmethylfluoxetine)
3-PHENYL-3-(4-TRIFLUOROMETHYL-PHENOXY)-PROPYLAMINE HYDROCHLORIDE
3-[4-(TRIFLUOROMETHYL)PHENOXY]-3-PHENYLPROPAN-1-AMINE HYDROCHLORIDE
1-(3-Amino-1-phenylpropoxy)-4-(trifluoromethyl)benzene hydrochloride
Benzenepropanamine, gamma-(4-(trifluoromethyl)phenoxy)-, hydrochloride
(+/-)-GAMMA-[4-(TRIFLUOROMETHYL)PHENOXY]-BENZENEPROPANAMINE HYDROCHLORIDE
[Molecular Formula]

C16H17ClF3NO
[MDL Number]

MFCD01321043
[MOL File]

57226-68-3.mol
[Molecular Weight]

331.76
Chemical PropertiesBack Directory
[storage temp. ]

-20°C
[solubility ]

H2O: >4 mg/mL
[form ]

solid
[color ]

yellow
[Stability:]

Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Safety DataBack Directory
[WGK Germany ]

3
Hazard InformationBack Directory
[Description]

Norfluoxetine is an active metabolite of the antidepressant fluoxetine. It is formed from fluoxetine by the cytochrome P450 (CYP) isoforms CYP2C9, CYP2C19, and CYP3A. Norfluoxetine inhibits serotonin (5-HT) uptake in rat brain synaptosomal membrane preparations (Ki = 44.7 nM) and isolated human platelets (IC50 = ~15 nM). It has been found in the tissues of fish exposed to wastewater effluent.
[Chemical Properties]

NORFLUOXETINE HYDROCHLORIDE is Light Beige to Light Brown Solid
[Uses]

Norfluoxetine hydrochloride has been used to examine if psychoactive pharmaceuticals in drinking water at environmental concentrations could induce neuronal gene expression. It has also been used to examine whether at environmental concentrations it can alter in vitro expression of autism spectrum disorders (ASD)-associated synaptic proteins in human neurons.
[Uses]

Norfluoxetine Hydrochloride is a metabolite of Fluoxetine (F597100), a selective serotonin reuptake inhibitor which is used as an antidepressant.
[Biochem/physiol Actions]

Norfluoxetine is an active metabolite of fluoxetine. It disturbs the production of estrogen in a co-culture model of the feto-placental unit.
[storage]

Store at -20°C
[References]

1) Veerman?et al.?(2013),?Slow delayed rectifier potassium current blockade contributes importantly to drug-induced long QT syndrome;?Circ. Arrythm. Electrophysiol.?6?1002 2) Lutz?et al.?(2013),?Stereoselective inhibition of CYP2C1 and CYP3A4 by fluoxetine and its metabolite: implications for risk assessment of multiple time-dependent inhibitor systems;?Drug Metab. Dispos.?41?2056 3) Wong?et al.?(1993),?Norfluoxetine enantiomers as inhibitors of serotonin uptake in rat brain;?Neuropsychopharmacology?8?337 4) Zuo?et al.?(2012),?Fluoxetine is a potent inhibitor of coxsackievirus replication.; Antimicrob. Agents Chemother.?56?4838 5) McClenaghan?et al.?(2016),?Polymodal activation of the TREK-2 K2P channel produces structurally distinct open states; J. Gen. Physiol.?147?497
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