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ChemicalBook--->CAS DataBase List--->57055-82-0

57055-82-0

57055-82-0 Structure

57055-82-0 Structure
IdentificationBack Directory
[Name]

4-(4-Morpholinobutylthio)phenol
[CAS]

57055-82-0
[Synonyms]

MoTP
33N14
4-(4-Morpholinobutylthio)phenol
4-(4-morpholin-4-ylbutylsulfanyl)phenol
Phenol, 4-[[4-(4-morpholinyl)butyl]thio]-
[Molecular Formula]

C14H21NO2S
[MDL Number]

MFCD00642470
[MOL File]

57055-82-0.mol
[Molecular Weight]

267.39
Chemical PropertiesBack Directory
[storage temp. ]

-20°C
[solubility ]

DMSO: ≥80mg/mL
[form ]

powder
[color ]

white to tan
[Stability:]

Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Safety DataBack Directory
[WGK Germany ]

3
Hazard InformationBack Directory
[Description]

MoTP (57055-82-0) specifically ablates zebrafish larval melanocytes. Melanocytotoxicity is dependent on tyrosinase activity.1,2 MoTP is a useful tool for elucidating melanocyte stem cell regeneration, recruitment and maintenance.3-5
[References]

1) Yang et al. (2006), Small molecule-induced ablation and subsequent regeneration of larval zebrafish melanocytes; Development, 133 3563 2) Yang et al. (2007), Mutations in gfpt1 and skiv2I2 cause distinct stage-specific defects in larval melanocyte regeneration in zebrafish; PLoS Genet., 3 e88 3) Hultman et al. (2009), Defects in ErbB-dependent establishment of adult melanocyte stem cells reveal independent origins for embryonic and regeneration melanocytes; PLoS Genet., 5 e1000544 4) Hultman et al. (2010), Differential contribution of direct-developing and stem cell-derived melanocytes to the zebrafish larval pigment pattern; Dev. Biol., 337 425 5) Hultman et al. (2008), Small molecule modifier screen for kit-dependent functions in zebrafish embryonic melanocytes; Zebrafish, 5 279
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