| Identification | Back Directory | [Name]
(R)-(+)-WARFARIN | [CAS]
5543-58-8 | [Synonyms]
(R)-WARFARIN
Dextrowarfarin
(R)-(+)-WARFARIN
Warfarin R-Isomer
Warfarin Impurity 16
Warfarin Impurity 16（Warfarin R-Isomer）
r-(+)-3-acetonybenzyl)-4-hydroxycoumarin
R-(+)-3-(ACETONYLBENZYL)-4-HYDROXYCOUMARIN
(S)-3-(alpha-Acetonylbenzyl)-4-hydroxycoumarin
(+)-3-[(R)-α-Acetonylbenzyl]-4-hydroxycoumarin
2-hydroxy-3-[(1R)-3-keto-1-phenyl-butyl]chromone
(+)-3-[(R)-1-Phenyl-3-oxobutyl]-4-hydroxycoumarin
2-hydroxy-3-[(1R)-3-oxo-1-phenylbutyl]chromen-4-one
(R)-4-hydroxy-3-(3-oxo-1-phenylbutyl)-2-benzopyrone
2-hydroxy-3-[(1R)-3-oxo-1-phenyl-butyl]chromen-4-one
(R)-4-Hydroxy-3-(3-oxo-1-phenylbutyl)-2H-chromen-2-one
Coumarin, 3-(a-acetonylbenzyl)-4-hydroxy-, R-(+)- (8CI)
4-Hydroxy-3-[(1R)-3-oxo-1-phenylbutyl]-2H-1-benzopyran-2-one
R-(+)-4-HYDROXY-3-(3-OXO-1-PHENYBUTYL)-2H-1-BENZOPYRAN-2-ONE
2H-1-Benzopyran-2-one, 4-hydroxy-3-[(1R)-3-oxo-1-phenylbutyl]-
(R)-(+)-4-HYDROXY-3-(3-OXO-1-PHENYLBUTYL)-2H-1-BENZOPYRAN-2-ONE
(+)-4-Hydroxy-3-[(R)-3-oxo-1-phenylbutyl]-2H-1-benzopyran-2-one
2H-1-Benzopyran-2-one, 4-hydroxy-3-(3-oxo-1-phenylbutyl)-, (R)-
2H-1-Benzopyran-2-one, 4-hydroxy-3-[(1R)-3-oxo-1-phenylbutyl]- (9CI)
R-(+)-3-Acetonybenzyl)-4-hydroxycoumarin, R-(+)-4-Hydroxy-3-(3-oxo-1-phenybutyl)-2H-1-benzopyran-2-one
(R)-(+)-WarfarinQ: What is
(R)-(+)-Warfarin Q: What is the CAS Number of
(R)-(+)-Warfarin Q: What is the storage condition of
(R)-(+)-Warfarin | [EINECS(EC#)]
226-908-9 | [Molecular Formula]
C19H16O4 | [MDL Number]
MFCD00272376 | [MOL File]
5543-58-8.mol | [Molecular Weight]
308.33 |
| Chemical Properties | Back Directory | [Melting point ]
≥170 °C | [Boiling point ]
515.2±50.0 °C(Predicted) | [density ]
1.307±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMF: soluble | [form ]
A crystalline solid | [pka]
4.50±1.00(Predicted) | [color ]
white to pale yellow |
| Hazard Information | Back Directory | [Chemical Properties]
White Solid | [Uses]
(R)-(+)-warfarin has been used to investigate whether enantiomers of warfarin stereoselectively interact with pregnane X nuclear receptor (PXR) to upregulate main drug/xenobiotic-metabolizing enzymes cytochrome P450 3A4 (CYP3A4) and cytochrome P450 2C9 (CYP2C9). It has also been used in HepG2 cells to study protein profiles | [Uses]
The R-(+)-form of Warfarin (W498500). Coumarin anticoagulant. | [Definition]
ChEBI: (R)-warfarin is a 4-hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one that has (R)-configuration (the racemate is warfarin, an anticoagulant drug and rodenticide). It is a conjugate acid of a (R)-warfarin(1-). It is an enantiomer of a (S)-warfarin. | [General Description]
The chiral carbon at position 9 produces two enantiomers, R- and S-warfarin. Commercially available warfarin (Coumadin or Jantoven) is a racemic mixture of S- and R-enantiomers. | [Biochem/physiol Actions]
Warfarin acts as a vitamin K antagonist. It is widely used to treat thromboembolic disorders. (R)-warfarin interacts with pregnane X receptor (PXR) and induces cytochrome P450 3A4 (CYP3A4) and CYP2C9 mRNAs expression in primary human hepatocyte cultures. |
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