| Identification | Back Directory | [Name]
CELECOXIB-D7 | [CAS]
544686-21-7 | [Synonyms]
CELECOXIB-D7
[2H7]-Celecoxib
4-[5-[2,3,5,6-tetradeuterio-4-(trideuteriomethyl)phenyl]-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonamide
Celecoxib D7Q: What is
Celecoxib D7 Q: What is the CAS Number of
Celecoxib D7 Q: What is the storage condition of
Celecoxib D7 Q: What are the applications of
Celecoxib D7 | [Molecular Formula]
C17H7D7F3N3O2S | [MDL Number]
MFCD08063418 | [MOL File]
544686-21-7.mol | [Molecular Weight]
388.42 |
| Hazard Information | Back Directory | [Description]
Celecoxib-d7 is intended for use as an internal standard for the quantification of celecoxib by GC- or LC-MS. Celecoxib is a selective inhibitor of COX-2 (IC50s = 22.9 and 0.05 μM for COX-1 and COX-2, respectively). It displays chemopreventive activity in multiple tumor types via proapoptotic effects that are independent of COX-2 inhibition. Formulations containing celecoxib have been used in the treatment of inflammation while circumventing the gastrointestinal toxicity associated with traditional non-sterodial anti-inflammatory drugs, however, the use of celecoxib has been tempered due to its ability to induce adverse cardiovascular events. | [Uses]
Celecoxib-d7 is the labeled analogue of Celecoxib (C251000), a selective cyclooxygenase-2 (COX-2) inhibitor. Anti-inflammatory. Used in treatment of familial adenomatous polyposis. |
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