| Identification | Back Directory | [Name]
PROGUANIL HYDROCHLORIDE | [CAS]
537-21-3 | [Synonyms]
M-5943
chlorproguanil
Chloroproguanil
PROGUANIL HYDROCHLORIDE
N1-3,4-Dichlorophenyl-N5-isopropyldiguanide
1-(3,4-Dichlorophenyl)-5-isopropylbiguanide
N-(3,4-Dichlorophenyl)-N'-isopropyldicarbonimido/ic diamide/imido
N-(3,4-Dichlorophenyl)-N'-(1-Methylethyl)iMidodicarboniMidic DiaMide
(1E)-1-[amino-(3,4-dichloroanilino)methylidene]-2-propan-2-ylguanidine
Imidodicarbonimidic diamide, N-(3,4-dichlorophenyl)-N'-(1-methylethyl)-
1-carbamimidoyl-1-(3,4-dichlorophenyl)-2-propan-2-yl-guanidine hydroch loride | [EINECS(EC#)]
208-660-3 | [Molecular Formula]
C11H15Cl2N5 | [MDL Number]
MFCD01732193 | [MOL File]
537-21-3.mol | [Molecular Weight]
288.18 |
| Chemical Properties | Back Directory | [Melting point ]
120-121 °C | [Boiling point ]
350.7±52.0 °C(Predicted) | [density ]
1.40±0.1 g/cm3(Predicted) | [pka]
10.77±0.10(Predicted) | [BCS Class]
1 |
| Hazard Information | Back Directory | [Uses]
PROGUANIL HYDROCHLORIDE is an antimalarial agent used in combination with Dapsone (D193250).
| [Definition]
ChEBI: Chlorproguanil is a dichlorobenzene. | [Clinical Use]
Malaria chemoprophylaxis | [Drug interactions]
Potentially hazardous interactions with other drugs
Anticoagulants: effect of warfarin possibly enhanced.
Antimalarials: avoid concomitant use with
artemether/lumefantrine; increased antifolate effect
with pyrimethamine. | [Metabolism]
Proguanil is metabolised in the liver to the active
metabolite, cycloguanil, and to p-chlorophenylbiguanide
which is inactive, mainly by cytochrome P450, CYP
2C19 and slightly by CYP 3A4. Unlike proguanil and
p-chlorophenylbiguanide, cycloguanil is not concentrated
in erythrocytes so concentrations of cycloguanil in
plasma and whole blood are similar. About 40-60% of
a dose of proguanil is excreted in the urine, 60% of this
as the unchanged drug, 30% as cycloguanil, and 8% as
p-chlorophenylbiguanide. About 10% of a dose is excreted
in the faeces. |
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| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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