| Identification | Back Directory | [Name]
1-OCTADECYL LPA | [CAS]
52977-29-4 | [Synonyms]
1-OCTADECYL LPA
1-OCTADECYL LYSOPHOSPHATIDIC ACID
1-Octadecyl Lysophosphatidic Acid Exclusive
1-Octadecyl Lysophosphatidic Acid (1-Octadecyl LPA)
1,2-Propanediol, 3-(octadecyloxy)-, 1-(dihydrogen phosphate) | [Molecular Formula]
C21H45O6P | [MDL Number]
MFCD11045839 | [MOL File]
52977-29-4.mol | [Molecular Weight]
424.55 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 10 mg/ml; DMSO: 10 mg/ml; Ethanol: 10 mg/ml; Ethanol:PBS (pH 7.2) ((1:1): 0.5 mg/ml | [form ]
A crystalline solid |
| Hazard Information | Back Directory | [Description]
1-Octadecyl lysophosphatidic acid (1-octadecyl LPA) is a LPA analog containing stearic acid at the sn-1 position. LPA binds to one of five different G protein linked receptors to mediate a variety of biological responses including cell proliferation, smooth muscle contraction, platelet aggregation, neurite retraction, and cell motility.1,2 Alkyl ether-linked LPA derivatives have a higher platelet aggregating activity than the acyl derivatives, most likely stemming from an alkyl-specific LPA receptor. For example, 1-octadecyl LPA has a platelet aggregating EC50 value of 9 nM versus 1-octadecanoyl LPA which has an EC50 value of 177 nM.3 | [storage]
Store at -20°C | [References]
1. Noguchi, K., Ishii, S., and Shimizu, T. Identification of p2y9/GPR23 as a novel G protein-coupled receptor for lysophosphatidic acid, structurally distant from the Edg family J. Biol. Chem. 278(28),25600-25606(2003).
2. Moolenaar, W.H. LPA: A novel lipid mediator with diverse biological actions Trends Cell Biol. 4(6),213-219(1994).
3. Tokumura, A., Sinomiya, J., Kishimoto, S., et al. Human platelets respond differentially to lysophosphatidic acids having a highly unsaturated fatty acyl group and alkyl ether-linked lysophosphatidic acids Biochem. J. 365,617-628(2002). |
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