| Identification | Back Directory | [Name]
Sevelamer | [CAS]
52757-95-6 | [Synonyms]
Sevelamer
Hsdb 7608
Sevelamer [inn:ban]
Epichlorohydrin-PAA 25 copolymer
Allylamine-epichlorohydrin copolymer
Allylamine polymer with 1-chloro-2,3-epoxypropane
2-Propen-1-amine, polymer with (chloromethyl)oxirane
Oxirane, (chloromethyl)-, polymer with 2-propen-1-amine | [Molecular Formula]
C6H12ClNO | [MDL Number]
MFCD09260188 | [MOL File]
52757-95-6.mol | [Molecular Weight]
149.619 |
| Hazard Information | Back Directory | [Uses]
Antihyper-phosphatemic. | [Brand name]
Renagel (Genzyme). | [Pharmaceutical Applications]
In patients on dialysis, Sevelamer or lanthanum salts can be used to maintain normal phosphate blood levels. Sevelamer is a polymer containing amine
groups. These protonated amine groups can react with the negatively charged phosphate groups via ionic binding
and prevent absorption of phosphate from the gut. Sevelamer is a hydrogel containing cross-linked polyallylamine chains. The negatively charged phosphate can be bound to the positively charged amine groups of the hydrogel in the intestines and removed via the faeces. | [Clinical Use]
Phosphate-binding agent | [Drug interactions]
Potentially hazardous interactions with other drugs
Antibacterials: reduces bioavailability of
ciprofloxacin.
Ciclosporin: possibly reduces ciclosporin
concentration.
Calcitriol: absorption may be impaired by sevelamer.
Mycophenolate: may reduce mycophenolate levels.
Tacrolimus: possibly reduces tacrolimus
concentration.
Thyroid hormones: possibly reduces levothyroxine
concentration. | [Metabolism]
Sevelamer is not systemically absorbed. |
|
| Company Name: |
Musechem
|
| Tel: |
+1-800-259-7612 |
| Website: |
www.musechem.com |
| Company Name: |
DC Chemicals
|
| Tel: |
021-58447131 13564518121 |
| Website: |
http://www.is0513.com/ShowSupplierProductsList927327/0.htm |
| Company Name: |
BOC Sciences
|
| Tel: |
16314854226 |
| Website: |
www.bocsci.com |
| Company Name: |
MedChemExpress
|
| Tel: |
021-58955995 |
| Website: |
www.medchemexpress.com |
|