| Identification | Back Directory | [Name]
Bunazosin hydrochloride | [CAS]
52712-76-2 | [Synonyms]
E-643
E 1015
E-1015
Detantol
Detantol-R
Bunzaosin Hcl
Bunazosin Hcl
Bunazosin, DETANTO
BUNAZOSIN HYDROCHLORIDE
Bunazosin hydrochloride USP/EP/BP
1-[4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-1,4-diazepan-1-yl]-1-butanone
1-[4-(4-amino-6,7-dimethoxyquinazolin-2-yl)-1,4-diazepan-1-yl]butan-1-one hydrochloride
1-(4-Amino-6，7-dimethoxyquinazolin-2-y1)-4-butyrylhexahydro-lH-1，4-diazepine hydrochloride | [Molecular Formula]
C19H28ClN5O3 | [MDL Number]
MFCD00941411 | [MOL File]
52712-76-2.mol | [Molecular Weight]
409.91 |
| Chemical Properties | Back Directory | [Melting point ]
280-282° | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
DMSO (Slightly, Heated), Methanol (Slightly, Heated) | [form ]
Solid | [color ]
White to Off-White |
| Hazard Information | Back Directory | [Description]
Bunazosin hydrochloride is a selective αl-adrenergic antagonist related to
prazosin and useful in the treatment of hypertension. | [Originator]
Eisai (Japan) | [Uses]
Bunazosin Hydrochloride is an α-1 adrenergic receptor antagonist that acts as an anti-cancer and anti-glaucoma drug. | [Definition]
ChEBI: Bunazosin hydrochloride is a member of quinazolines. | [Manufacturing Process]
17.0 g of 2-chloro-4-amino-6,7-dimethoxyquinazoline and 18.2 g of Nformylhomopiperazine
are added to 170 ml of butanol and the whole is
refluxed with stirring for 3 h. After completion of the reaction, the mixture is
cooled, and the crystals thus precipitated are filtered out, washed with a small
quantity of ethanol and air-dried. 25.0 g of crude 2-homopiperazino-4-amino-
6,7-dimethoxyquinazoline are obtained.
A solution of 2-homopiperazino-4-amino-6,7-dimethoxyquinazoline in 60 ml of
acetone is added dropwise to a solution of 2-butylcarboxylic acid chloride in
acetone under stirring and ice-cooling. After completion of the addition, the
stirring is continued for additional 1 h to complete the reaction. The crystals
thus precipitated are filtered out and the 1-(4-amino-6,7-dimethoxy-2-
quinazolinyl)hexahydro-4-(1-oxobutyl)-1H-1,4-diazepine, melting point 280-
282°C (recrystallized from a mixture of methanol-ethanol) is obtained. | [Brand name]
DETANTOL | [Therapeutic Function]
Antihypertensive |
|
| Company Name: |
HBCChem, Inc.
|
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+1-510-219-6317 |
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www.warehouse-sample-usa.com |
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