| Identification | Back Directory | [Name]
cloprednol | [CAS]
5251-34-3 | [Synonyms]
RS-4691
Novacort
Synestan
Syntestan
Cloradryn
cloprednol
Cloprednole
cloprednol USP/EP/BP
Methylprednisolone Impurity 33 (Cloprednol)
6-Chloro-11β,17,21-trihydroxypregna-1,4,6-triene-3,20-dione
6-Chloro-11beta,17,21-trihydroxypregna-1,4,6-triene-3,20-dione
(11β)-6-Chloro-11,17,21-trihydroxypregna-1,4,6-triene-3,20-dione
Pregna-1,4,6-triene-3,20-dione, 6-chloro-11,17,21-trihydroxy-, (11β)-
(8S,9S,10R,11S,13S,14S,17R)-6-chloro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-9,11,12,14,15,16-hexahydro-8H-cyclopenta[a]phenanthren-3-one | [EINECS(EC#)]
226-052-6 | [Molecular Formula]
C21H25ClO5 | [MDL Number]
MFCD00200364 | [MOL File]
5251-34-3.mol | [Molecular Weight]
392.876 |
| Chemical Properties | Back Directory | [Melting point ]
>125°C (dec.) | [Boiling point ]
600.3±55.0 °C(Predicted) | [density ]
1.40±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C Freezer | [solubility ]
Ethyl Acetate (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
12.30±0.70(Predicted) | [color ]
White to Off-White |
| Hazard Information | Back Directory | [Originator]
Syntestan,Syntex,W. Germany,1980 | [Uses]
A systematic corticosteroid. Anti-inflammatory. | [Definition]
ChEBI: Cloprednol is a 21-hydroxy steroid. | [Manufacturing Process]
A mixture of 5 g of the 21-acetate of 6α-chlorohydrocortisone, 7 g of chloranil
and 100 cc of n-amyl alcohol was refluxed for 16 hours, cooled and diluted
with ether. The solution was successively washed with water, 5% sodium
carbonate solution and water, dried over anhydrous sodium sulfate, filtered
and evaporated to dryness under reduced pressure. Chromatographic
purification of the residue yielded the 21-acetate of 6-chloro-δ1,4,6-
pregnatriene-11β,17α,21-triol-3,20-dione. | [Therapeutic Function]
Glucocorticoid |
|
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