| Identification | Back Directory | [Name]
Prinaberel | [CAS]
524684-52-4 | [Synonyms]
ERB 041
PRINABEREL
WAY-202041
Prinaberel (ERB 041)
2-(3-Fluoro-4-hydroxyphenyl)-
7-vinylbenzoxazol-5-ol
7-Ethenyl-2-(3-fluoro-4-hydroxyphenyl)-5-benzoxazolol
5-Benzoxazolol, 7-ethenyl-2-(3-fluoro-4-hydroxyphenyl)-
2-(3-Fluoro-4-hydroxyphenyl)-7-vinyl-1,3-benzoxazol-5-ol | [Molecular Formula]
C15H10FNO3 | [MDL Number]
MFCD09954141 | [MOL File]
524684-52-4.mol | [Molecular Weight]
271.24 |
| Chemical Properties | Back Directory | [Melting point ]
250-252 ºC | [Boiling point ]
451.6±45.0 °C(Predicted) | [density ]
1.413 | [storage temp. ]
room temp | [solubility ]
DMSO: ≥25mg/mL | [form ]
powder | [pka]
7.50±0.20(Predicted) | [color ]
white to tan | [InChIKey]
MQIMZDXIAHJKQP-UHFFFAOYSA-N |
| Hazard Information | Back Directory | [Chemical Properties]
Pale Yellow Solid | [Uses]
Prinaberel is a potent ERβ agonist; displays >200-fold selectivity for ERβ over ERα (IC50 values are 5 and 1216 nM for human ERβ and ERα; 3.1 and 620 nM for rat ERβ and ERα; and 3.7 and 750 nM for mouse ERβ and ERα respectively).
| [Biological Activity]
ERB-041 is a potentselective estrogen ERβ receptor agonist (IC50 ERβ: 5.4 nM; > 200-fold selective over ERα). ERβ plays a minor role in mediating estrogen action in the uterusthe hypothalamus/pituitarythe skeletonand other classic estrogen target tissues. Howevera clear role for ERβ has been established in the ovarycardiovascular systemand brain as well as in animal models of inflammation including arthritisendometriosisinflammatory bowel diseaseand sepsis. There is increasing interest in finding ERβ agonists for potential use in a variety of clinical applications without triggering classic estrogenic side effects. | [storage]
Store at -20°C |
|
| Company Name: |
LGM Pharma
|
| Tel: |
1-(800)-881-8210 |
| Website: |
www.lgmpharma.com |
|