Identification | Back Directory | [Name]
HO-PEG5-CH2COOtBu | [CAS]
52026-48-9 | [Synonyms]
HO-PEG5-CH2COOH HO-PEG5-CH2COOtBu Hydroxy-PEG5-CH2COOH Hydroxy-PEG5-acetic acid | [Molecular Formula]
C12H24O8 | [MDL Number]
MFCD31656910 | [MOL File]
52026-48-9.mol | [Molecular Weight]
296.31 |
Hazard Information | Back Directory | [Biological Activity]
HO-PEG5-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | [References]
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
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