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ChemicalBook--->CAS DataBase List--->51876-97-2

51876-97-2

51876-97-2 Structure

51876-97-2 Structure
IdentificationBack Directory
[Name]

1,3-Dioxo-1H-benzo[de]isoquinoline-2(3H)-acetic acid sodium salt
[CAS]

51876-97-2
[Synonyms]

AY-22284A
Alrestatin sodium
sodium,2-(1,3-dioxobenzo[de]isoquinolin-2-yl)acetate
1,3-Dioxo-1H-benz[de]isoquinoline-2(3H)-acetic acid sodium salt
1,3-Dioxo-1H-benzo[de]isoquinoline-2(3H)-acetic acid sodium salt
[MOL File]

51876-97-2.mol
Hazard InformationBack Directory
[Originator]

Alrestatin,BIOMOL
[Uses]

Enzyme inhibitor (aldose reductase).
[Manufacturing Process]

1,3-Dioxo-1H-benz[de]isoquinoline-2(3H)-acetic acid:
1,8-Naphthalic acid anhydride (110 g, 0.556 mole), glycine (48 g, 0.64 mole) and dimethylformamide (750 ml) are heated and stirred at reflux for 2 hr. The homogeneous dark solution is cooled to about 100°C and 750 ml of hot water is added slowly to the stirred solution. The reaction mixture is cooled and allowed to stand in a refrigerator for 16 hr. The precipitate is collected and recrystallized from ethanol, using decolorizing charcoal, to give the title compound, MP: 271°-272°C.
In practice it is usually used as sodium salt.
[Therapeutic Function]

Aldose reductase inhibitor
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