| Hazard Information | Back Directory | [Description]
Catumaxomab is an anti-Ep-CAM monoclonal antibody, it has been designed to induce more efficient killing of epithelial tumor cells. More specifically, catumaxomab is a bispecific trifunctional antibody (trAb). In addition to its EpCAM recognition arm, it possesses an anti-CD3 arm that targets the T-cell antigen CD3; binding to the CD3 receptor activates T cells to release cytotoxic cytokines and to promote T cell-mediated lysis. In essence, catumaxomab consists of one half of an anti-Ep-CAM antibody and one half of an anti-CD3 antibody. The trifunctionality comes into play with an intact Fc region that selectively binds to FCg receptor-positive accessory cells, such as macrophages, dendritic cells, and natural killer (NK) cells that promote phagocytosis and antibody-dependent cell cytotoxicity. As a trAb that brings the requisite immune effector cells in close proximity to the tumor cells, catumaxomab destroys tumor cells possessing the surface antigen Ep-CAM via simultaneous activation and complex crosstalk of T cells and accessory immune cells. While it has gained approval for the intraperitoneal (i.p.) treatment of malignant ascites caused by Ep-CAM-positive metastatic epithelial-derived tumors, it is also being evaluated for the treatment of ovarian and gastric cancers. | [Originator]
TRION
Pharma (Germany) | [Brand name]
Removab |
|
| Company Name: |
NCE Biomedical Co.,Ltd.
|
| Tel: |
4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988 |
| Website: |
www.is0513.com/ShowSupplierProductsList15748/0.htm |
| Company Name: |
SPIRO PHARMA
|
| Tel: |
|
| Website: |
www.spiropharma.com.cn |
| Company Name: |
Biolab Reagents
|
| Tel: |
027-65279366 18108604862 |
| Website: |
www.biolabreagent.com/ |
|