| Identification | Back Directory | [Name]
GW441756 | [CAS]
504433-23-2 | [Synonyms]
Gw
CS-1085
W 441756
GW 441756
GW441756, >98%
GW441756 USP/EP/BP
GW 441756; GW-441756
3-[(1-methylindol-3-yl)methylidene]-1H-pyrrolo[3,2-b]pyridin-2-one
-3-((1-methyl-1H-indol-3-yl)methylene)-1H-pyrrolo[3,2-b]pyridin-2(3H)-one
(Z)-3-((1-methyl-1H-indol-3-yl)methylene)-1H-pyrrolo[3,2-b]pyridin-2(3H)-one
3-[(1-METHYLINDOL-3-YL)METHYLIDENE]-1H-PYRROLO[3,2-B]PYRIDIN-2-ONE;HYDROCHLORIDE
1,3-DIHYDRO-3-[(1-METHYL-1H-INDOL-3-YL)METHYLENE]-2H-PYRROLO[3,2-B]PYRIDIN-2-ONE
2H-Pyrrolo[3,2-b]pyridin-2-one, 1,3-dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]- | [Molecular Formula]
C17H13N3O | [MDL Number]
MFCD08703104 | [MOL File]
504433-23-2.mol | [Molecular Weight]
275.305 |
| Chemical Properties | Back Directory | [Boiling point ]
568.0±50.0 °C(Predicted) | [density ]
1.31±0.1 g/cm3(Predicted) | [storage temp. ]
Store at RT | [solubility ]
Soluble in DMSO (up to 5 mg/ml). | [form ]
solid | [pka]
11.04±0.20(Predicted) | [color ]
Orange | [Stability:]
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| Hazard Information | Back Directory | [Description]
GW-441756 (504433-23-2) is a potent and selective TrkA kinase inhibitor (IC50 = 2 nM). | [Uses]
GW 441756 is an effective Trk binder, a novel bioactive molecule used in the treatment of neuroblastoma in infants. | [Definition]
ChEBI: 3-[(1-methyl-3-indolyl)methylidene]-1H-pyrrolo[3,2-b]pyridin-2-one is a member of indoles. | [Biological Activity]
Potent, selective inhibitor of the NGF receptor tyrosine kinase A (TrkA) (IC 50 = 2 nM). Displays > 100-fold selectivity over a range of other kinases. | [storage]
Store at -20°C | [References]
1) Wood et al. (2004) Discovery and in vitro evaluation of potent TrkA kinase inhibitors: oxindole and aza-oxindoles. Bioorg. Med. Chem. Lett. 14 953
2) Takemoto et al. (2015) Neuroprotection elicited by nerve growth factor and brain-derived neurotrophic factor released from astrocytes in response to methylmercury; Environ. Toxicol. Pharmacol. 40 199 [Focus Citation] |
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