| Identification | Back Directory | [Name]
CHAETOGLOBOSIN A | [CAS]
50335-03-0 | [Synonyms]
CHAETOGLOBOSIN
CHAETOGLOBOSINB
CHAETOGLOBOSINM
CHAETOGLOBOSINE
CHAETOGLOBOSINL
chaetoglobosins
CHAETOGLOBOSIN A
CHAETOGLOBOSIN A, B, C, D, E, F, K, Q, R, T
18-dimethyl-,(7s,13e,16s,17e,19r,21e)-ol-3-yl)-1
3H-Cyclotridec[d]oxireno[f]isoindole-8,11,12(13H)-trione
(13)cytochalasa-13,17,21-triene-1,20,23-trione,6,7-epoxy-19-hydroxy-10-(1h-ind
4,7,14,14a,15,15a,16a,16b-Octahydro-7-hydroxy-14-(1H-indol-3-ylmethyl)-4,6,15,15a-tetramethyl-
(1E,4S,5E,7R,9E,11aR,14S,14aR,15S,15aR,16aS,16bR)-4,7,14,14a,15,15a,16a,16b-Octahydro-7-hydroxy-14-(1H-indol-3-ylmethyl)-4,6,15,15a-tetramethyl-3H-cyclotridec[d]oxireno[f]isoindole-8,11,12(13H)-trione
3H-Cyclotridec[d]oxireno[f]isoindole-8,11,12(13H)-trione, 4,7,14,14a,15,15a,16a,16b-octahydro-7-hydroxy-14-(1H-indol-3-ylmethyl)-4,6,15,15a-tetramethyl-, (1E,4S,5E,7R,9E,11aR,14S,14aR,15S,15aR,16aS,16bR)- | [Molecular Formula]
C32H36N2O5 | [MDL Number]
MFCD08273781 | [MOL File]
50335-03-0.mol | [Molecular Weight]
528.64 |
| Chemical Properties | Back Directory | [Occurrence]
A complex macrocyclic alkaloid, this base has been isolated from Diplodia rnacrospora. Chaetoglobosin A possesses the property of inhibiting growth
in wheat coleoptiles. | [Melting point ]
188°C | [Boiling point ]
608.81°C (rough estimate) | [density ]
1.1705 (rough estimate) | [refractive index ]
1.5800 (estimate) | [storage temp. ]
?20°C | [solubility ]
DMSO: soluble10mg/mL | [form ]
solid | [pka]
17.32±0.30(Predicted) | [color ]
Yellow | [Stability:]
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. |
| Hazard Information | Back Directory | [Definition]
ChEBI: A cytochalasan alkaloid isolated from Chaetomium globosum and Calonectria morganii. | [Description]
Chaetoglobosin A (50335-03-0) is a cytochalasin analog which targets filamentous actin. Displays cytotoxic effects against human colorectal HCT116 cells, IC50=3.15 μM.1 Preferentially induces apoptosis in chronic lymphocytic leukemia cells via targeting the cytoskeleton.2 Enhances the fibrinolytic activity of vascular endothelial cells.3 | [Uses]
Chaetoglobosin A is a mycotoxic cytochalasan compound. | [storage]
+4°C | [References]
1) Li et al. (2014), Chaetoglobosins from Chaetomium globosum, an endophytic fungus in Ginkgo biloba, and their phytotoxic and cytotoxic activities; J. Agric. Food Chem., 62 3734
2) Knudsen et al. (2014), Chaetoglobosin A preferentially induces apoptosis in chronic lymphocytic leukemia cells by targeting the cytoskeleton; Leukemia, 28 1289
3) Shinohara et al. (2000), Enhancement of fibrinolytic activity of vascular endothelial cells by chaetoglobosin A, crinipellin B, geodin and triticone B; J. Antibiot. (Tokyo), 53 262 |
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