| Identification | Back Directory | [Name]
Tat-NR2B9c | [CAS]
500992-11-0 | [Synonyms]
Tat-NR2B9c
Tat-NR2B9c/NA-1
Tat-NR2B9c, >98%
500992-11-0/1834571-04-8
L-Valine, L-tyrosylglycyl-L-arginyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-glutaminyl-L-arginyl-L-arginyl-L-arginyl-L-lysyl-L-leucyl-L-seryl-L-seryl-L-isoleucyl-L-α-glutamyl-L-seryl-L-α-aspartyl- | [Molecular Formula]
C105H188N42O30 | [MOL File]
500992-11-0.mol | [Molecular Weight]
2518.88 |
| Chemical Properties | Back Directory | [density ]
1.52±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [form ]
Solid | [color ]
White to off-white | [Water Solubility ]
Water : ≥ 50 mg/mL (19.85 mM) |
| Hazard Information | Back Directory | [Biological Activity]
Tat-NR2B9c (NA-1) is a 20-mer peptide composed of a membrane-permeant HIV-1 T at protein transduction domain sequence (a.a. 47-57) N-terminal to the NMDA receptor (NMDAR) GluN2B carboxyl tail sequence KLSSIESDV th at blocks intracellular NMDAR-PSD-95 interaction-induced neurotoxic signaling without affecting NMDAR-mediated synaptic activity or calcium influx. NA-1 protects cultured cortical neurons from NMDA excitotoxicity (50 nM; 20/40/100 μM NMDA) and reduces focal ischemic brain damage in rats in vivo (3 μmol/kg iv. bolus 1 hr post MCAO onset). | [storage]
Store at -20°C |
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Musechem
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DC Chemicals
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