| Chemical Properties | Back Directory | [Boiling point ]
627.9±55.0 °C(Predicted) | [density ]
1.210±0.06 g/cm3(Predicted) | [solubility ]
DMSO : 41.67 mg/mL (117.89 mM; Need ultrasonic) | [form ]
Solid | [pka]
14.93±0.20(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Definition]
ChEBI: N-[4-methyl-2-(4-morpholinyl)-6-quinolinyl]cyclohexanecarboxamide is an aminoquinoline. | [Biological Activity]
NCGC00092410 is a potent, selective, and nonsugar glucocerebrosidase (GC) inhibitor, with an IC50 of 31 nM. NCGC00092410 shows no activity against the related hydrolases at concentrations up to 77 μM. NCGC00092410, a GC chaperone, and increases the activity and lysosomal localization of glucocerebrosidase in mutant cell lines. NCGC00092410 can be used for the research of Gaucher disease[1].
NCGC00092410 (7.3-130 nM; 25 min) inhibits the GC activity at various substrate concentrations (10-150 μM) in a dose-dependent manner[1].NCGC00092410 (55-40 μM; 2 d) increases the GC activity in the N370S mutant fibroblasts[1].NCGC00092410 (40 μM; 60-72 h) increases the lysosomal localization of GC in gaucher fibroblasts[1]. | [References]
[1]. Zheng W, et, al. Three classes of glucocerebrosidase inhibitors identified by quantitative high-throughput screening are chaperone leads for Gaucher disease. Proc Natl Acad Sci U S A. 2007 Aug 7;104(32):13192-7. |
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DC Chemicals
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021-58447131 13564518121 |
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http://www.is0513.com/ShowSupplierProductsList927327/0.htm |
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