| Identification | Back Directory | [Name]
(4-Chloro-3-nitrophenyl)(4-(2-fluorophenyl)piperazin-1-yl)Methanone | [CAS]
432020-20-7 | [Synonyms]
SMI481
NPPM6748481
NPPM 6748481
NPPM 6748-481
NPPM-6748-481
SID: 164348711
SMI-481 SMI 481
1-(4-Chloro-3-nitrobenzoyl)-4-(2-fluorophenyl)-piperazine
(4-Chloro-3-nitrophenyl)(4-(2-fluorophenyl)piperazin-1-yl)Methanone
Methanone, (4-chloro-3-nitrophenyl)[4-(2-fluorophenyl)-1-piperazinyl]- | [Molecular Formula]
C17H15ClFN3O3 | [MDL Number]
MFCD03575351 | [MOL File]
432020-20-7.mol | [Molecular Weight]
363.771 |
| Chemical Properties | Back Directory | [Boiling point ]
543.3±50.0 °C(Predicted) | [density ]
1.411±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: soluble5mg/mL, clear | [form ]
powder | [pka]
1.04±0.10(Predicted) | [color ]
white to beige |
| Hazard Information | Back Directory | [Uses]
SMI-481 is a yeast phosphatidylinositol transfer proteins (PITP) Sec14 inhibitor. | [Biological Activity]
SMI481 is a selective small-molecule inhibitor (SMI) of the yeast phosphatidylinositol transfer protein (PITP) Sec14a key regulator of phosphoinositide signalingregulating membrane trafficking through the trans-Golgi network and endosomal systems. SMI481 has an IC50 value of 211 ± 19 nM in vitro against S. cerevisiae Sec14 (WT) in a phosphatidylinositol (PtdIns) transfer assay measuring exchange of PtdIns and phosphatidylcholine between membranes and inhibited Sec14-dependent growth of WT yeast with an IC50 of 2.87 ± 0.55 μM. SMI481μs activity is believed to involve binding in the Sec14 hydrophobic cavitya new target for studying phosphoinositide signaling with more selectivity than th at afforded by lipid kinase–directed strategies. |
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SPIRO PHARMA
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