| Identification | Back Directory | [Name]
dibenzo[b,d]furan-3-ylboronic acid | [CAS]
395087-89-5 | [Synonyms]
3-DBFBA
Dibenzofuran-3-boronic acid
Dibenzofuran-3-ylboronic acid
B-3-dibenzofuranylBoronic acid
(3-Dibenzofuranyl)boronic acid
Boronic acid, 3-dibenzofuranyl-
Dibenzo[b,d]furan-3-boronicacid
Boronic acid,B-3-dibenzofuranyl-
dibenzo[b,d]furan-3-ylboronic acid | [Molecular Formula]
C12H9BO3 | [MDL Number]
MFCD26516274 | [MOL File]
395087-89-5.mol | [Molecular Weight]
212.01 |
| Chemical Properties | Back Directory | [Boiling point ]
438.5±37.0 °C(Predicted) | [density ]
1.34±0.1 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,2-8°C | [pka]
8.20±0.30(Predicted) |
| Hazard Information | Back Directory | [Uses]
Dibenzo[b,d]furan-3-ylboronic acid can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly used in laboratory research and development and chemical and pharmaceutical production processes. | [Synthesis]
In a 300 ml three-necked flask, 7.2 g of 4-bromodibenzofuran was dissolved in ?78° C. anhydrous tetrahydrofuran (THF) under an argon atmosphere. Then, 20 ml of an n-butyl lithium-n-hexane solution (1.6 M, 1.1 eq) was added and stirred for 1 hour. 4.23 ml (1.3 eq) of trimethoxyborane (B(OMe)3) was added and stirred for 2 hours, and the temperature of the reaction system was increased to room temperature. 200 ml of 1 N hydrochloric acid was added into the reactant and stirred for 3 hours. An organic layer was separated, and solvents were distilled off. In the crude product thus obtained, hexane was added. Precipitated product was filtered to obtain 4.94 g of dibenzofuran-4-boronic acid as a white solid (yield 80percent). The product was measured by FAB-MS, and dibenzofuran-4-boronic acid having a molecular weight of 212 was detected. |
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