| Identification | Back Directory | [Name]
Tarafenacin | [CAS]
385367-47-5 | [Synonyms]
CS-929
SVT407776
Tarafenacin
Tarafenacin, >=98%
Tarafenacin(SVT-40776)
SVT-40776 (Tarafenacin)
SVT-40776; SVT40776; SVT 40776
[(3R)-1-azabicyclo[2.2.2]octan-3-yl] N-(3-fluorophenyl)-N-[(3,4,5-trifluorophenyl)methyl]carbamate
N-(3-Fluorophenyl)-N-[(3,4,5-trifluorophenyl)methyl]carbamic acid (3R)-1-azabicyclo[2.2.2]oct-3-yl ester
Carbamic acid, N-(3-fluorophenyl)-N-[(3,4,5-trifluorophenyl)methyl]-, (3R)-1-azabicyclo[2.2.2]oct-3-yl ester | [Molecular Formula]
C21H20F4N2O2 | [MDL Number]
MFCD19443715 | [MOL File]
385367-47-5.mol | [Molecular Weight]
408.389 |
| Chemical Properties | Back Directory | [Boiling point ]
483.4±45.0 °C(Predicted) | [density ]
1.38 | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Powder | [pka]
8.80±0.33(Predicted) |
| Hazard Information | Back Directory | [Biological Activity]
tarafenacin is a selective antagonist of m3 muscarinic receptor with ki value of 0.19nm [1].tarafenacin is a novel quinuclidine derivative and is developed as an antimuscarinic drug for treatment of overactive bladder. it shows a 203-fold selectivity with m3 receptor over m2 receptor. tarafenacin reduces the maximum carbachol response at concentrations of 10nm and 100nm in mouse isolated bladder. in mouse atrial preparations, tarafenacin slightly attenuates the effects on heart rate caused by carbachol. tarafenacin shows a 199-fold urinary affinity against cardiac affinity. it is a highly potent antagonist in the bladder and lacks any relevant effect in atria at the same range of concentrations. in the guinea pig model, tarafenacin significantly changes the bladder contraction amplitude. it inhibits 25% of spontaneous bladder contractions at dose of 17.1nmol/kg [1]. | [storage]
Store at -20°C | [References]
[1] salcedo c, davalillo s, cabellos j, et al. in vivo and in vitro pharmacological characterization of svt-40776, a novel m3 muscarinic receptor antagonist, for the treatment of overactive bladder. british journal of pharmacology, 2009, 156(5): 807-817. |
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BOC Sciences
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16314854226 |
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www.bocsci.com |
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