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ChemicalBook--->CAS DataBase List--->363571-83-9

363571-83-9

363571-83-9 Structure

363571-83-9 Structure
IdentificationBack Directory
[Name]

3,5-dibromo-N'-{(E)-[2,5-dimethyl-1-(3-nitrophenyl)-1H-pyrrol-3-yl]methylidene}-4-hydroxybenzohydrazide
[CAS]

363571-83-9
[Synonyms]

3,5-Dibromo-N'-((2,5-dimethyl-1-(3-nitrophenyl)-1H-pyrrol-3-yl)methylene)-4-hydroxybenzohydrazide
3,5-dibromo-N'-{(E)-[2,5-dimethyl-1-(3-nitrophenyl)-1H-pyrrol-3-yl]methylidene}-4-hydroxybenzohydrazide
Benzoic acid, 3,5-dibromo-4-hydroxy-, 2-[[2,5-dimethyl-1-(3-nitrophenyl)-1H-pyrrol-3-yl]methylene]hydrazide
[Molecular Formula]

C20H16Br2N4O4
[MDL Number]

MFCD02636553
[MOL File]

363571-83-9.mol
[Molecular Weight]

536.17
Chemical PropertiesBack Directory
[density ]

1.71±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

DMSO : 125 mg/mL (233.14 mM)
[form ]

Solid
[pka]

5.43±0.25(Predicted)
[color ]

Light yellow to yellow
Hazard InformationBack Directory
[Biological Activity]

Kinesore is an inhibitor of the KLC2-SKIP interaction.
[in vitro]

Remarkably, in kinesore-treated cells, the microtubule network is entirely reorganized into a series of loops and bundles. In addition, the lysosomal compartment accumulates in a juxtanuclear position, where there are relatively few microtubules. At 50 μM kinesore, this phenotype is highly penetrant, with 95±2.4% (n=3, total of 200 cells) of cells exhibiting a reorganized nonradial microtubule network. In titration experiments, in cells treated for 1 h, this phenotype becomes apparent at a concentration of 25 μM kinesore, with relatively little effect at or below concentrations of 12.5 μM. The effect is reversible because a 2-h washout of kinesore from cells treated for 1 h led to the reestablishment of the radial microtubule array. This kinesore-induced reorganization of the microtubule network is observed in a panel of mammalian normal and cancer cell lines. In wild-type cells, 50 μM kinesore induces the remodeling of the microtubule network and the formation of extensive m icrotubule-rich projections. This phenotype is strongly suppressed in Kif5B knockout cells, confirming that microtubule remodeling induced by kinesore is dependent upon the presence of kinesin-1.

[target]

KLC2-SKIP.

[storage]

Store at -20°C
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