| Identification | Back Directory | [Name]
F16 | [CAS]
36098-33-6 | [Synonyms]
F16
F16
(F-16
Compound F16)
F-16;COMPOUND F16
F16/Cell proliferation inhibitor (F16)
4-[(E)-2-(INDOL-3-YL)ETHENYL]-N-METHYLPYRIDINIUM IODIDE
3-[2-(1-methylpyridin-1-ium-4-yl)ethenyl]-1H-indole,iodide
4-[(1E)-2-(1H-INDOL-3-YL)ETHENYL]-1-METHYL-PYRIDINIUM IODIDE | [Molecular Formula]
C16H15IN2 | [MDL Number]
MFCD00050298 | [MOL File]
36098-33-6.mol | [Molecular Weight]
362.21 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
≤500μg/ml in ethanol;20mg/ml in DMSO;25mg/ml in dimethyl formamide | [form ]
Orange solid. | [color ]
Yellow to orange |
| Hazard Information | Back Directory | [Uses]
F16 is a cell-permeable mitochondrial toxin with apoptotic and necrotic action in tumor cell lines. | [Biological Activity]
f16 is a small, cationic, lipophilic, and fluorescent molecule capable of binding preferentially to mitochondrial membranes and disrupts their function. f16 is a potential antitumor agent.f16 affected growth in some mouse and human breast cancer cell lines. f16 resulted in a dramatic decrease in the number of cells in s phase and an increase in the percentage of cells in g1 phase [1]. prolonged incubation with 3 μm f16 led to increased cell death of f16-sensitive cells but not of f16-resistant ones. f16 accumulation in mitochondria induced mitochondrial damage characterized by imbalance of volumetric homeostasis, failure to synthesize atp, cytochrome c release and increased production of reactive oxy gen species [1]. f16 incubation decreased the cellular atp pool in both parental eph4-a6 and bcl-2-overexpressing eph4-a6.c13 and eph4-a6.c18 cells in a time-dependent manner [1]. treatment with f16 promoted early release of cytochrome c in transformed eph4-a6 cells. treatment with f16 (0.3-3 μm) resulted in the characteristic apoptotic dna laddering in the eph4-a6 cells. f16-induced mitochondrial dysfunction triggers apoptosis or necrosis. f16 induced necrosis in various cell lines resistant to apoptosis [2]. | [References]
[1] fantin v r, berardi m j, scorrano l, et al. a novel mitochondriotoxic small molecule that selectively inhibits tumor cell growth[j]. cancer cell, 2002, 2(1): 29-42.
[2] fantin v r, leder p. f16, a mitochondriotoxic compound, triggers apoptosis or necrosis depending on the genetic background of the target carcinoma cell[j]. cancer research, 2004, 64(1): 329-336. |
|
| Company Name: |
Musechem
|
| Tel: |
+1-800-259-7612 |
| Website: |
www.musechem.com |
| Company Name: |
DC Chemicals
|
| Tel: |
021-58447131 13564518121 |
| Website: |
http://www.is0513.com/ShowSupplierProductsList927327/0.htm |
|