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GKK1032B is a fungal metabolite that has antiproliferative and antibacterial activities. GKK1032B inhibits the growth of HeLa S3 cervical and MCF-7 breast cancer cells and Vero cells. It also inhibits the growth of B. subtilis and M. tuberculosis. | [in vitro]
Among them, GKK1032B showed significant cytotoxicity against human osteosarcoma cell line MG63 with an IC50 value of 3.49 μmol·L-1, and a primary mechanistic study revealed that it induced the apoptosis of MG63 cellsvia caspase pathway activation._x000D_
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Reference: Chin J Nat Med. 2022 Jan;20(1):67-73. https://pubmed.ncbi.nlm.nih.gov/35101251/ | [target]
GKK1032B can induce the apoptosis of human osteosarcoma MG63 cells through caspase pathway activation. |
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