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ChemicalBook--->CAS DataBase List--->349087-34-9

349087-34-9

349087-34-9 Structure

349087-34-9 Structure
IdentificationBack Directory
[Name]

JX401
[CAS]

349087-34-9
[Synonyms]

JX401
p38 MAP Kinase Inhibitor VI, JX401
1-[2-Methoxy-4-(methylthio)benzoyl]-4-benzylpiperidine
1-[2-Methoxy-4-(methylthio)benzoyl]-4-(phenylmethyl)piperidine
p38 MAP Kinase Inhibitor VI, JX401 - CAS 349087-34-9 - Calbiochem
Methanone, [2-methoxy-4-(methylthio)phenyl][4-(phenylmethyl)-1-piperidinyl]-
[Molecular Formula]

C21H25NO2S
[MDL Number]

MFCD02038777
[MOL File]

349087-34-9.mol
[Molecular Weight]

355.49
Chemical PropertiesBack Directory
[storage temp. ]

Store at RT
[solubility ]

Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml).
[form ]

Off-white solid
[color ]

White
[Stability:]

Stable for 2 years from date of purchase as supplied. PROTECT FROM MOISTURE. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Safety DataBack Directory
[Hazard Codes ]

N
[Risk Statements ]

50/53
[Safety Statements ]

60-61
[RIDADR ]

UN 3077 9/PG 3
Hazard InformationBack Directory
[Description]

JX401 (349087-34-9) is a potent, cell-permeable inhibitor of p38α (IC50 = 32 nM). No inhibition of p38β was observed at 10 μM.
[Uses]

JX-401 is a potent, reversible inhibitor of the p38α isoform of MAP kinase (IC50 = 32 nM). It does not inhibit the p38γ isoform. JX-401 is effective in mammalian cells, as it blocks the differentiation of myoblasts into myotubes.[Cayman Chemical]
[Uses]

JX-401 is an inhibitor of p38α isoform MAP kinase, blocks the differentiation of myoblasts and myotubes.
[Definition]

ChEBI:[2-methoxy-4-(methylthio)phenyl]-[4-(phenylmethyl)-1-piperidinyl]methanone is a N-acylpiperidine and a member of benzamides.
[Biological Activity]

Potent, reversible inhibitor of p38 α that displays no activity on the p38 γ isoform (IC 50 values are 32 nM and > 10 μ M respectively). Inhibits the differentiation of myoblasts to myotubes in mammalian cells in culture.
[storage]

Store at RT
[References]

1) Friedmann et al. (2006), JX401,a p38α inhibitor containing a 4-benzylpiperidine motif, identified via a novel screening system in yeast; Mol. Pharmacol., 70 1395.
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