| Identification | Back Directory | [Name]
Bifluranol | [CAS]
34633-34-6 | [Synonyms]
BX-341
Bifluranol
Phenol, 4,4'-[(1R,2S)-1-ethyl-2-methyl-1,2-ethanediyl]bis[2-fluoro-, rel- | [Molecular Formula]
C17H18F2O2 | [MDL Number]
MFCD00864665 | [MOL File]
34633-34-6.mol | [Molecular Weight]
292.32 |
| Chemical Properties | Back Directory | [Melting point ]
158-159° | [Boiling point ]
361.6±37.0 °C(Predicted) | [density ]
1?+-.0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
8.85±0.31(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Definition]
ChEBI: (2S,3R)-bifluranol is a 4,4'-pentane-2,3-diylbis(2-fluorophenol) that has (2S,3R)-stereoconfiguration. It is an enantiomer of a (2R,3S)-bifluranol. | [Biological Activity]
Bifluranol (BX341) has anti-androgenic activity. | [in vivo]
The absorption, distribution and excretion of Bifluranol have been studied in mouse, rat, ferret and dog. It is readily absorbed following oral administration, but blood concentrations of Bifluranol are low due to hepatic uptake and biliary excretion. After intravenous administration of [ 3 H]it to rats (200 μg/kg) and ferrets (60 μg/kg) the blood concentrations of 3 H decreases rapidly for the first 2 to 3 h, with the decrease being more rapid in females ( 18 min for rat, 30 min for ferret) than males (1.0 h for rat, 1.4 h for ferret). This is followed by a much slower decline (40 h for rat). , 20 h for ferret) to concentrations at 96 h of less than 15 ng Bifluranol equivalents mL -1 (rat) or 1 ng Bifluranol equivalents mL -1 (ferret). | [storage]
Store at -20°C |
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