| Identification | Back Directory | [Name]
1-Piperazineethanol, 4-(2-phenyl-4-quinazolinyl)- | [CAS]
345651-04-9 | [Synonyms]
BVDV IN-1
1-Piperazineethanol, 4-(2-phenyl-4-quinazolinyl)- | [Molecular Formula]
C20H22N4O | [MDL Number]
MFCD10154938 | [MOL File]
345651-04-9.mol | [Molecular Weight]
334.41 |
| Chemical Properties | Back Directory | [Boiling point ]
472.2±45.0 °C(Predicted) | [density ]
1?+-.0.06 g/cm3(Predicted) | [storage temp. ]
4°C, protect from light | [solubility ]
DMSO : 250 mg/mL (747.59 mM; Need ultrasonic) | [form ]
Solid | [pka]
14.96±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Biological Activity]
BVDV-IN-1 is a non-nucleoside inhibitor (NNI) of bovine viral diarrhea virus (BVDV), with an EC50 of 1.8 μM. BVDV-IN-1 directly binds to a hydrophobic pocket of the BVDV RdRp. BVDV-IN-1 has antiviral activity against BVDV resistant to NNI thiosemicarbazone (TSC)[1].
BVDV-IN-1 (compound 1.9) binds to a hydrophobic pocket of the BVDV RNA-dependent RNA polymerase (RdRp)[1].BVDV-IN-1 inhibits the replication of TSC-resistant BVDV variants in vitro[1]. | [storage]
4°C, protect from light | [References]
[1]. Gabriela A Fernández, et al. Design and Optimization of Quinazoline Derivatives: New Non-nucleoside Inhibitors of Bovine Viral Diarrhea Virus. Front Chem. 2020 Dec 10;8:590235. |
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