| Identification | Back Directory | [Name]
(2S, 3S, 4R)-2-STEAROYLIMINO-1,3,4-OCTADECANETRIOL-1-PHOSPHOCHOLINE (SACCHAROMYCES CEREVISIAE) | [CAS]
34354-88-6 | [Synonyms]
DS-CeraMide Y3S
C18-PHYTOCERAMIDE
N-STEAROYL-PHYTOSPHINGOSINE
YEAST N-18:0 PHYTOSPHINGOSINE
C18 3-Hydroxy DihydroceraMide
C18 Phytoceramide (t18:0/18:0)
2S,3S,4R-2-StearoylaMide-1,3,4-octadecanetriol
D-ribo-1,3,4-Trihydroxy-2-octadecanoylaMidooctadecane
N-STEAROYL-PHYTOSPHINGOSINE (SACCHAROMYCES CEREVISIAE)
N-[(1S,2S,3R)-2,3-Dihydroxy-1-(hydroxyMethyl)heptadecyl]octadecanaMide
Octadecanamide, N-[(1S,2S,3R)-2,3-dihydroxy-1-(hydroxymethyl)heptadecyl]-
(2S, 3S, 4R)-2-STEAROYLIMINO-1,3,4-OCTADECANETRIOL-1-PHOSPHOCHOLINE (SACCHAROMYCES CEREVISIAE) | [EINECS(EC#)]
812-962-6 | [Molecular Formula]
C36H73NO4 | [MDL Number]
MFCD02259296 | [MOL File]
34354-88-6.mol | [Molecular Weight]
583.97 |
| Chemical Properties | Back Directory | [Melting point ]
122-124°C | [Boiling point ]
718℃ at 10hPa | [density ]
0.994-1.014 at 20℃ | [vapor pressure ]
0Pa at 25℃ | [storage temp. ]
Hygroscopic, -20°C Freezer, Under inert atmosphere | [solubility ]
Chloroform : Methanol = 3 : 1 (Slightly), Pyridine (Slightly, Heated, Sonicated) | [form ]
Solid | [color ]
White to Off-White | [InChIKey]
IEZRNEGTKRQRFV-LFBNJJMOSA-N | [SMILES]
C(N[C@@H](CO)[C@H](O)[C@H](O)CCCCCCCCCCCCCC)(=O)CCCCCCCCCCCCCCCCC | [LogP]
12.01 at 25℃ and pH7 |
| Hazard Information | Back Directory | [Description]
N-Stearoyl-phytosphingosine (SPS), sphingolipids frequently found in mammalian skin, plants, and yeast, have been used in cosmetics. In mice, treatment with SPS inhibited histamine-induced scratching behavior and vascular permeability. This agent inhibited the expression of the allergic cytokines IL-4 and TNF-a and the activation of the transcription factors NF-jB and c-jun in histamine-stimulated skin tissues[1]. | [Uses]
An intercellular lipid that benefits skin hydration and protects against SLS irritation. | [Definition]
ChEBI: N-octadecanoyl-4-hydroxysphinganine is a phytoceramide in which the ceramide N-acyl group is specified as octadecanoyl (stearoyl). It is a N-acylphytosphingosine and a N-stearoyl-sphingoid base. | [References]
[1] Kwon-Ryeol Ryu. “Anti-scratching Behavioral Effects of N-Stearoyl-phytosphingosine and 4-Hydroxysphinganine in Mice.” Lipids 45 7 (2010): 613–618.
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