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ChemicalBook--->CAS DataBase List--->343351-67-7

343351-67-7

343351-67-7 Structure

343351-67-7 Structure
IdentificationBack Directory
[Name]

NSC697923
[CAS]

343351-67-7
[Synonyms]

NSC697923
NSC697923 USP/EP/BP
2-Nitro-5-tosylfuran
2-Nitro-5-(toluene-4-sulfonyl)-furan
2-[(4-Methylphenyl)sulfonyl]-5-nitrofur
2-[(4-Methylphenyl)sulfonyl]-5-nitrofuran
Furan, 2-[(4-Methylphenyl)sulfonyl]-5-nitro-
[Molecular Formula]

C11H9NO5S
[MDL Number]

MFCD01925132
[MOL File]

343351-67-7.mol
[Molecular Weight]

267.258
Chemical PropertiesBack Directory
[Melting point ]

124-126°C
[Boiling point ]

443.8±40.0 °C(Predicted)
[density ]

1.416±0.06 g/cm3(Predicted)
[storage temp. ]

?20°C
[solubility ]

DMSO: soluble20mg/mL, clear
[form ]

powder
[color ]

white to beige
[Stability:]

Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Safety DataBack Directory
[Hazard Codes ]

Xn
[Risk Statements ]

22-41
[Safety Statements ]

26-39
[WGK Germany ]

3
Hazard InformationBack Directory
[Description]

NSC-69723 (343351-67-7) is a selective inhibitor of the E2 ubiquitin-conjugating enzyme, Ubc13-Uev1A. Does not inhibit UbcH5c activity. Impedes the formation of the Ubc13 and inhibits NF-κB activation in activated B cell-like diffuse large B-cell lymphoma (ABC-DLBCL) cells.1?Blocks proliferation and survival of both ABC-DLBCL and germinal center B cell-like (GCB)-DLBCL cell lines, and survival of primary DLBCL cells. NSC-69723 acts via covalent bonding to E2 active site thiol.2,3?Induces neuroblastoma cell death via activation of p53 and JNK.4
[Uses]

NSC 697923 is a cell-permeable and selective inhibitor of the ubiquitin-conjugating (E2) enzyme Ubc13-Uev1A and exhibits potent cytotoxicity in a panel of Neuroblastoma (NB) cell lines. NSC 697923 also inhibits the proliferation and survival of diffuse large B-cell lymphoma cells (DLBCL).
[storage]

+4°C
[References]

1) Pulvino et al.?(2012),?Inhibition of proliferation and survival of diffuse large B-cell lymphoma cells by a small-molecule inhibitor of the ubiquitin-conjugating enzyme Ubc13-Uev1A; Blood,?120?1668 2) Strickson?et al.?(2013),?The anti-inflammatory drug BAY 11-7082 suppresses the MyD88-dependent signaling network by targeting the ubiquitin system; Biochem. J.,?451?427 3) Hodge?et al.?(2015),?Covalent Inhibition of Ubc13 Affects Ubiquitin Signaling and Reveals Active Site Elements Important for Targeting; ACS Chem. Biol.,?10?1718 4) Cheng?et al.?(2014),?A small-molecule inhibitor of UBE2N induces neuroblastoma cell death via activation of p53 and JNK pathways; Cell Death Dis.,?5?e1079
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