| Identification | Back Directory | [Name]
L-Leucine, N-[4-[4-[[(2R)-2-hydroxy-2-[4-hydroxy-3-[(methylsulfonyl)amino]phenyl]ethyl]amino]-1-piperidinyl]benzoyl]- | [CAS]
340757-05-3 | [Synonyms]
β3-AR agonist 2
Β3-AR AGONIST 2
β3-AR agonist 2
β3AR agonist 2,β3 AR agonist 2
L-Leucine, N-[4-[4-[[(2R)-2-hydroxy-2-[4-hydroxy-3-[(methylsulfonyl)amino]phenyl]ethyl]amino]-1-piperidinyl]benzoyl]- | [Molecular Formula]
C27H38N4O7S | [MDL Number]
MFCD31544462 | [MOL File]
340757-05-3.mol | [Molecular Weight]
562.678 |
| Hazard Information | Back Directory | [Description]
β3-AR agonist 2 is a potent and selective β3-adrenergic receptor (β3-AR) agonist with an EC50 of 8 nM. β3-AR agonist 2 (Compound 26e) is found to be potent and selective at the β3 receptor, nearly completely abolishes intrinsic activity at either the β1 or β2 receptor[1]. β3-AR agonist 2 (Compound 26e) has significant thermogenesis effects on human β3-adrenergic receptor transgenic mice. β3-AR agonist 2 acts as a potential drug for the treatment of human obesity and type II diabetes[1]. | [References]
[1]. Hu B, et al. (4-Piperidin-1-yl)phenyl amides: potent and selective human beta(3) agonists. J Med Chem. 2001 Apr 26;44(9):1456-66. |
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