Identification | Back Directory | [Name]
1-(4-CHLOROPHENYL)-4-(TRIFLUOROMETHYL)[1,2,4]TRIAZOLO[4,3-A]QUINOXALINE | [CAS]
338773-13-0 | [Synonyms]
R-8507 R8507,R 8507 1-(4-CHLOROPHENYL)-4-(TRIFLUOROMETHYL)[1,2,4]TRIAZOLO[4,3-A]QUINOXALINE | [Molecular Formula]
C16H8ClF3N4 | [MDL Number]
MFCD00974644 | [MOL File]
338773-13-0.mol | [Molecular Weight]
348.71 |
Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 16 mg/ml; DMF:PBS (pH 7.2) (1:5): 0.16 mg/ml; DMSO: 2 mg/ml | [form ]
A crystalline solid |
Hazard Information | Back Directory | [Description]
R-8507 is a small molecule antagonist of the TNF-α type 1 receptor (TNF-αRI).1 It inhibits the expression of intercellular adhesion molecule-1 (ICAM-1) induced by TNF-α and IL-1β with EC50 values of 2.45 and 3.79 μM, respectively, in an ELISA using A549 lung epithelial cells.{|Gururaja2007|} It also disrupts the interaction of the TNF-αRI with receptor interacting protein 1 (RIP1) and TNF-αR-associated death domain protein (TRADD), preventing internalization of the receptor complex. | [References]
1. Gururaja, T.L., Yung, S., Ding, R., et al. A class of small molecules that inhibit TNFα-induced survival and death pathways via prevention of interactions between TNFαRI, TRADD, and RIP1 Chem. Biol. 14(10),1105-1118(2007). |
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Key Organics Ltd.
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+44 (0) 1840-212137 |
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www.keyorganics.net |
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