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ChemicalBook--->CAS DataBase List--->338773-13-0

338773-13-0

338773-13-0 Structure

338773-13-0 Structure
IdentificationBack Directory
[Name]

1-(4-CHLOROPHENYL)-4-(TRIFLUOROMETHYL)[1,2,4]TRIAZOLO[4,3-A]QUINOXALINE
[CAS]

338773-13-0
[Synonyms]

R-8507
R8507,R 8507
1-(4-CHLOROPHENYL)-4-(TRIFLUOROMETHYL)[1,2,4]TRIAZOLO[4,3-A]QUINOXALINE
[Molecular Formula]

C16H8ClF3N4
[MDL Number]

MFCD00974644
[MOL File]

338773-13-0.mol
[Molecular Weight]

348.71
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

DMF: 16 mg/ml; DMF:PBS (pH 7.2) (1:5): 0.16 mg/ml; DMSO: 2 mg/ml
[form ]

A crystalline solid
Hazard InformationBack Directory
[Description]

R-8507 is a small molecule antagonist of the TNF-α type 1 receptor (TNF-αRI).1 It inhibits the expression of intercellular adhesion molecule-1 (ICAM-1) induced by TNF-α and IL-1β with EC50 values of 2.45 and 3.79 μM, respectively, in an ELISA using A549 lung epithelial cells.{|Gururaja2007|} It also disrupts the interaction of the TNF-αRI with receptor interacting protein 1 (RIP1) and TNF-αR-associated death domain protein (TRADD), preventing internalization of the receptor complex.
[References]

1. Gururaja, T.L., Yung, S., Ding, R., et al. A class of small molecules that inhibit TNFα-induced survival and death pathways via prevention of interactions between TNFαRI, TRADD, and RIP1 Chem. Biol. 14(10),1105-1118(2007).
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