| Identification | Back Directory | [Name]
TTP 22 | [CAS]
329907-28-0 | [Synonyms]
TTP 22
CS-886
TTP 22, >97%
TTP22; TTP-22
TTP 22, >=98%
3-(5-P-TOLYLTHIENO[2,3-D]PYRIMIDIN-4-YLTHIO)PROPANOIC ACID
3-[[5-(4-Methylphenyl)thieno[2,3-d]pyriMidin-4-yl]thio]propanoic acid
Propanoic acid, 3-[[5-(4-Methylphenyl)thieno[2,3-d]pyriMidin-4-yl]thio]-
3-{[5-(4-Methylphenyl)thieno[2,3-d]pyrimidin-4-yl]sulfanyl}propanoic acid
3-[2-(3-HYDROXY-5-METHOXYPHENYL)ETHYL]-6-METHOXY-2-(3-METHYL-2-BUTEN-1-YL)PHENOL
TTP 22 3-[[5-(4-Methylphenyl)thieno[2,3-d]pyrimidin-4-yl]thio]propanoic acid | [Molecular Formula]
C16H14N2O2S2 | [MDL Number]
MFCD02654497 | [MOL File]
329907-28-0.mol | [Molecular Weight]
330.42 |
| Chemical Properties | Back Directory | [storage temp. ]
Keep in dark place,Sealed in dry,Store in freezer, under -20°C | [solubility ]
insoluble in H2O; ≥16.5 mg/mL in DMSO; ≥7.85 mg/mL in EtOH with gentle warming and ultrasonic | [form ]
solid | [color ]
White to gray |
| Hazard Information | Back Directory | [Uses]
TTP 22 is a CK2 inhibitor. | [Biological Activity]
ttp 22 is a high affinity, atp-competitive casein kinase 2 (ck2) inhibitor.casein kinase 2 (ck2) noticeably stands out against a background of the kinase family due to its constitutive catalytic activity with the ability to phosphorylate more than 300 physiological substrates. these features make ck2 appear greatly diverse points of cell signaling pathways and be involved in processes leading to the development of various disorders, especially cancer. thus, currently ck2 is regarded as druggable protein kinase target and can be used for the development of antitumor, anti-inflammatory and antiviral drugs. | [in vitro]
kinetic studies of ttp 22 showed that activity of (thieno[2,3-d]pyrimidin-4-ylthio)carboxylic acids moiety was a result of its competition with atp molecule for the binding site. inhibition constant (ki) for ttp 22 was 40 nm. initial in vitro tests of ttp 22 and it analog on four serine/threonine (ask1, jnk3, aurora a and rock 1) and three tyrosine protein kinases (fgfr1, met and tie2) revealed their remarkable specificity towards ck2 [1]. | [IC 50]
= 0.1 μm; ki= 40 nm | [storage]
Store at +4°C | [References]
[1] golub ag,bdzhola vg,briukhovetska nv,balanda ao,kukharenko op,kotey im,ostrynska ov,yarmoluk sm. synthesis and biological evaluation of substituted (thieno[2,3-d]pyrimidin-4-ylthio)carboxylic acids as inhibitors of human protein kinase ck2. eur j med chem.2011 mar;46(3):870-6. |
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