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ChemicalBook--->CAS DataBase List--->32908-73-9

32908-73-9

      32908-73-9 Structure

      32908-73-9 Structure
      IdentificationBack Directory
      [Name]

      MAST CELL DEGRANULATING PEPTIDE
      [CAS]

      32908-73-9
      [Synonyms]

      MCD
      isulfide)
      MCD PEPTIDE
      Peptide 401
      IKCNCKRHVIKPHICRKICGKN-NH2
      MCD PEPTIDE (APIS MELLIFERA)
      MAST CELL DEGRANULATING PEPTIDE
      MAST CELL DEGRANULATING (MCD) PEPTIDE
      MCD-PEPTIDE (HONEYBEE, APIS MELLIFERA)
      mastcelldegranulatingpeptide(honeybee)
      MAST CELL DEGRANULATING PEPTIDE (APIS MELLIFERA)
      Mast Cell Degranulating (MCD) Peptide Peptide 401
      mastcelldegranulatingpeptide(honeybeereduced)cyclic(3-15),(5-19)-bis(d
      ILE-LYS-CYS-ASN-CYS-LYS-ARG-HIS-VAL-ILE-LYS-PRO-HIS-ILE-CYS-ARG-LYS-ILE-CYS-GLY-LYS-ASN-NH2
      H-ILE-LYS-CYS-ASN-CYS-LYS-ARG-HIS-VAL-ILE-LYS-PRO-HIS-ILE-CYS-ARG-LYS-ILE-CYS-GLY-LYS-ASN-NH2
      H-ILE-LYS-+CYS-ASN-++CYS-LYS-ARG-HIS-VAL-ILE-LYS-PRO-HIS-ILE-+CYS-ARG-LYS- ILE-++CYS-GLY-LYS-ASN-NH2
      H-ILE-LYS-CYS-ASN-CYS-LYS-ARG-HIS-VAL-ILE-LYS-PRO-HIS-ILE-CYS-ARG-LYS-ILE-CYS-GLY-LYS-ASN-NH2 (RANDOM CYCLIZATION)
      L-Ile-L-Lys-L-Cys(1)-L-Asn-L-Cys(2)-L-Lys-L-Arg-L-His-L-Val-L-Ile-L-Lys-L-Pro-L-His-L-Ile-L-Cys(1)-L-Arg-L-Lys-L-Ile-L-Cys(2)-Gly-L-Lys-L-Asn-NH2
      L-Aspartamide, L-isoleucyl-L-lysyl-L-cysteinyl-L-asparaginyl-L-cysteinyl-L-lysyl-L-arginyl-L-histidyl-L-valyl-L-isoleucyl-L-lysyl-L-prolyl-L-histidyl-L-isoleucyl-L-cysteinyl-L-arginyl-L-lysyl-L-isoleucyl-L-cysteinylglycyl-L-lysyl-, cyclic (3→15),(5→19)-bis(disulfide)
      [EINECS(EC#)]

      628-471-3
      [Molecular Formula]

      C110H192N40O24S4
      [MDL Number]

      MFCD00167557
      [MOL File]

      32908-73-9.mol
      [Molecular Weight]

      2587.24
      Chemical PropertiesBack Directory
      [density ]

      1.50±0.1 g/cm3(Predicted)
      [storage temp. ]

      −20°C
      [solubility ]

      Soluble in DMSO
      [form ]

      Solid
      [color ]

      White to off-white
      Safety DataBack Directory
      [WGK Germany ]

      3
      [RTECS ]

      OQ5980000
      Hazard InformationBack Directory
      [Uses]

      Peptide 401, a potent mast cell degranulating factor from bee venom, suppresses the increased vascular permeability due to intradermal injection of various smooth muscle spasmogens (histamine, and 5-HT).
      [Biological Activity]

      Peptide 401 is a potent mast cell degranulation peptide derived from bee venom that inhibits vascular permeability.
      [in vivo]

      Peptide 401 substantially inhibits the oedema provoked by subplantar injection of carrageenin or intra-articular injection of turpentine in the rat. The ED 50 of 401 is c. 0.1 mg/kg. The anti-inflammatory effect is assessed by measurement of the increased 125 I-albumin content of an injected site in comparison with an uninjected contralateral site. Peptide 401 also suppresses the increased vascular permeability due to intradermal injection of various smooth muscle spasmogens (histamine, bradykinin, 5-hydroxytryptamine (5-HT), and prostaglandins). Peptide 401 (MCD peptide) contains 22 residues and occurs in the venom of the common European honey bee to the extent of about 2% by weight . It has powerful anti-inflammatory activity (at doses as low as 0.1 mg/kg) in a variety of animal models, ie, hind paw oedema in the rat induced by carrageenin or turpentine, adjuvant arthritis in the rat, and increased skin permeability in the rat resulting from subcut aneous injection of bradykinin, prostaglandin E1 kallikrein, histamine and 5-hydroxytryptamine (5-HT). It has a powerful degranulating effect on mast cells and involves the release of histamine and other pharmacologically active agents.

      [target]

      < /table>

      serotonin

      Histamine Receptor

      [IC 50]

      serotonin; Histamine Receptor
      [References]

      [1] Hanson JM, et al. Anti-inflammatory property of 401 (MCD-peptide), a peptide from the venom of the bee Apis mellifera (L.). Br J Pharmacol. 1974 Mar;50(3):383-92. DOI:10.1111/j.1476-5381.1974.tb09613.x
      [2] Banks BE, et al. Anti-inflammatory activity of bee venom peptide 401 (mast cell degranulating peptide) andcompound 48/80 results from mast cell degranulation in vivo. Br J Pharmacol. 1990 Feb;99(2):350-4. DOI:10.1111/j.1476-5381.1990.tb14707.x
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