| Identification | Back Directory | [Name]
MT477 | [CAS]
328069-91-6 | [Synonyms]
MT477
tetramethyl 6'-[(2,5-dioxopyrrolidin-1-yl)acetyl]-7'-methoxy-5',5'-dimethyl-5',6'-dihydrospiro[1,3-dithiole-2,1'-thiopyrano[2,3-c]quinoline]-2',3',4,5-tetracarboxylate | [Molecular Formula]
C31H30N2O12S3 | [MDL Number]
MFCD01068171 | [MOL File]
328069-91-6.mol | [Molecular Weight]
718.77 |
| Hazard Information | Back Directory | [Description]
MT477 is PKC-α inhibitor. MT477 interfered with PKC activity as well as phosphorylation of Ras and ERK1/2 in H226 human lung carcinoma cells. It also induced poly-caspase-dependent apoptosis. MT477 had a dose-dependent (0.006 to 0.2 mM) inhibitory effect on cellular proliferation of H226, MCF-7, U87, LNCaP, A431 and A549 cancer cell lines as determined by in vitro proliferation assays. |
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PHARMEKS Ltd.
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+7 (495) 702-9648 |
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www.pharmeks.com |
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