| Identification | Back Directory | [Name]
(2R)-3-Cyclopentyl-2-[4-(methanesulfonyl)phenyl]-N-(thiazol-2-yl)propionamide | [CAS]
300353-13-3 | [Synonyms]
Ro 0281675
Ro 28-1675
RO 028-1675;RO 0281675
RO 28-1675 - RO 28-0450, (R)-
(2R)-3-Cyclopentyl-2-[4-(methanesulfonyl)phenyl]-N-(thiazol-2-yl)propionamide
BenzeneacetaMide, α-(cyclopentylMethyl)-4-(Methylsulfonyl)-N-2-thiazolyl-, (αR)- | [Molecular Formula]
C18H22N2O3S2 | [MOL File]
300353-13-3.mol | [Molecular Weight]
378.51 |
| Chemical Properties | Back Directory | [density ]
1.306 | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 50 mg/mL (132.10 mM; Need ultrasonic) | [form ]
Powder | [pka]
8.65±0.50(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Definition]
ChEBI: (2R)-3-cyclopentyl-2-(4-methylsulfonylphenyl)-N-(2-thiazolyl)propanamide is a member of acetamides. | [Biological Activity]
RO-28-1675 is a potent allosteric activator of glucokinase with EC50 of 54 nM. It can be used in type 2 diabetes research. | [in vitro]
RO-28-1675 can reverse the inhibitory action of the human glucokinase regulatory protein (GKRP).
| [in vivo]
RO-28-1675 (50 mg/kg; po) reduces blood glucose levels in wild-type C57BL/6J mice.
RO-28-1675 (10 mg/kg; po) displays lower clearance and higher oral bioavailability.
| Animal Model: | 10 weeks old male C57BL/6J mice | | Dosage: | 50 mg/kg | | Administration: | Oral administration | | Result: | Reduced blood glucose levels. | | Animal Model: | C57BL/6J mice | | Dosage: | 10 mg/kg | | Administration: | Oral administr ation | | Result: | AUC 0-inf (5150 ng? h/mL), C max (1140 μg/mL) , T max (3.3 hours ), F po (92.8%) with 10 mg/kg orally administered. | | [target]
EC50: 54 nM (glucokinase) |
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Musechem
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