| Identification | Back Directory | [Name]
treosulfan | [CAS]
299-75-2 | [Synonyms]
CB-2562
Cb 40067
Leo 40067
NSC 39069
treosulfan
TREOSULPHAN
THREOSULFAN
Dihydroxymyleran
Dihydroxybusulfan
L-Dihydroxy-Busulfan
L-Threitol 1,4-dimethanesulfonate
L-Threitol-1,4-bis(methanesulfonate)
L-Threitol, 1,4-bis(methanesulfonate)
(2S,3S)-Threitol 1,4-bismethanesulfonate
1,2,3,4-butanetetrol 1,4-dimethanesulfonate
(2S,3S)-1-O,4-O-Di(methylsulfonyl)-L-threitol
1,2,3,4-Butanetetrol,1,4-diMethanesulfonate, (2S,3S)-
1,2,3,4-Butanetetrol, 1,4-dimethanesulfonate, [S-(R*,R*)]- | [EINECS(EC#)]
206-081-0 | [Molecular Formula]
C6H14O8S2 | [MDL Number]
MFCD02258964 | [MOL File]
299-75-2.mol | [Molecular Weight]
278.301 |
| Chemical Properties | Back Directory | [Melting point ]
76-78 °C | [Boiling point ]
359.3°C (rough estimate) | [density ]
1.305 (estimate) | [refractive index ]
1.5630 (estimate) | [storage temp. ]
Store at -20°C | [solubility ]
Acetone (Slightly), DMSO (Slightly), Methanol (Slightly), Water (Slightly) | [form ]
Solid | [pka]
12.36±0.20(Predicted) | [color ]
Off-White to Pale Beige | [CAS DataBase Reference]
299-75-2 | [IARC]
1 (Vol. 26, Sup 7, 100A) 2012 | [EPA Substance Registry System]
Treosulfan (299-75-2) |
| Safety Data | Back Directory | [RIDADR ]
2811 | [HazardClass ]
6.1(b) | [PackingGroup ]
III | [Safety Profile]
Confirmed carcinogen.
Poison by intravenous route. Human
mutation data reported. When heated to
decomposition it emits toxic fumes of SOx. | [Hazardous Substances Data]
299-75-2(Hazardous Substances Data) | [Toxicity]
LDLo intravenous in dog: 222mg/kg |
| Hazard Information | Back Directory | [General Description]
Odorless white crystalline powder. | [Air & Water Reactions]
Water soluble. Slowly hydrolyzes: decomposes within 3 hours at pH 7.5 and 77°F. . | [Fire Hazard]
Flash point data for treosulfan are not available; however, treosulfan is probably combustible. | [Uses]
Treosulfan is used as myeloablative agent in conditioning regimen prior to allogeneic hematopoietic stem cell transplantation (HSCT)??. It can also be an effective agent for conditioning children with inborn errors of immunity (IEI). | [Definition]
ChEBI: Treosulfan is a methanesulfonate ester. | [Clinical Use]
Alkylating agent for ovarian cancer | [Drug interactions]
Potentially hazardous interactions with other drugs
None known | [Metabolism]
Treosulfan is a prodrug of a bifunctional alkylating agent, converted in vivo to epoxide compounds. Approximately 30
% of the substance is excreted unchanged in the urine within 24 hours, nearly 90
% of which is within the first 6 hours after administration. | [storage]
Store at -20°C |
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