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ChemicalBook--->CAS DataBase List--->29553-70-6

29553-70-6

29553-70-6 Structure

29553-70-6 Structure
IdentificationBack Directory
[Name]

4-(3-carboxyphenyl)pyridine-2,5-dicarboxylic acid
[CAS]

29553-70-6
[Synonyms]

4-CPPC (4CPPC)
4-(3-carboxyphenyl)pyridine-2,5-dicarboxylic acid
2,5-Pyridinedicarboxylic acid, 4-(3-carboxyphenyl)-
[Molecular Formula]

C14H9NO6
[MOL File]

29553-70-6.mol
[Molecular Weight]

287.22
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

DMSO: soluble
[form ]

A crystalline solid
[color ]

White to off-white
Spectrum DetailBack Directory
[Spectrum Detail]

4-(3-carboxyphenyl)pyridine-2,5-dicarboxylic acid(29553-70-6)1HNMR
Hazard InformationBack Directory
[Biological Activity]

4-CPPC is an inhibitor of macrophage migration inhibitory factor-2 (MIF-2; IC50 = 27 μM).1 It is selective for MIF-2 over MIF-1 (IC50 = 450 μM). It inhibits MIF-2, but not MIF-1, binding to CD74 in vitro when used at a concentration of 10 μM. 4-CPPC (5, 10, and 25 μM) inhibits MIF-2-induced ERK1/2 phosphorylation in primary human skin fibroblasts.
[References]

1.Tilstam, P.V., Pantouris, G., Corman, M., et al.A selective small-molecule inhibitor of macrophage migration inhibitory factor-2 (MIF-2), a MIF cytokine superfamily member, inhibits MIF-2 biological activityJ. Biol. Chem.294(49)18522-18531(2019)
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