| Identification | Back Directory | [Name]
OTX 008 | [CAS]
286936-40-1 | [Synonyms]
PTX 008
Calixarene 0118
OTX008 (Calixarene 0118
Calix[4]arene compound 0118
OTX008 (Synonyms: Calixarene 0118
Acetamide, 2,2',2'',2'''-[pentacyclo[19.3.1.13,7.19,13.115,19]octacosa-1(25),3,5,7(28),9,11,13(27),15,17,19(26),21,23-dodecaene-25,26,27,28-tetrayltetrakis(oxy)]tetrakis[N-[2-(dimethylamino)ethyl]- | [Molecular Formula]
C52H72N8O8 | [MDL Number]
MFCD28396412 | [MOL File]
286936-40-1.mol | [Molecular Weight]
937.18 |
| Chemical Properties | Back Directory | [Boiling point ]
1143.4±65.0 °C(Predicted) | [density ]
1.155±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 1 mg/ml; DMSO: 2 mg/ml; Ethanol: 5 mg/ml; PBS (pH 7.2): 0.5 mg/ml | [form ]
A crystalline solid | [pka]
13.84±0.46(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Biological Activity]
OTX008 (Calixarene 0118, PTX008), a calixarene derivative, is a selective inhibitor of galectin-1 (Gal1) with antitumor activity. | [in vivo]
OTX008 inhibits growth of A2780-1A9 xenografts. OTX008 treatment is associated with down-regulation of Gal1 and Ki67 in treated tumours, as well as decreased microvessel density and VEGFR2 expression. Finally, combination studies show OTX008 synergy with several cytotoxic and targeted therapies, principally when OTX008 is administered first. | [target]
| Target | Value | galectin-1
() |
| [storage]
Store at -20°C |
|
| Company Name: |
DC Chemicals
|
| Tel: |
021-58447131 13564518121 |
| Website: |
http://www.is0513.com/ShowSupplierProductsList927327/0.htm |
|