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ChemicalBook--->CAS DataBase List--->2767422-72-8

2767422-72-8

2767422-72-8 Structure

2767422-72-8 Structure
IdentificationBack Directory
[Name]

HS-276
[CAS]

2767422-72-8
[Synonyms]

HS-276
[Molecular Formula]

C24H29N5O2
[MOL File]

2767422-72-8.mol
[Molecular Weight]

419.52
Chemical PropertiesBack Directory
[density ]

1.28±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

DMSO : 50 mg/mL (119.18 mM; ultrasonic and warming and adjust pH to 2 with HCl and heat to 80°C)
[form ]

Solid
[pka]

12.32±0.43(Predicted)
[color ]

Off-white to light yellow
Spectrum DetailBack Directory
[Spectrum Detail]

HS-276(2767422-72-8)1HNMR
Hazard InformationBack Directory
[Biological Activity]

HS-276 is an orally activepotent and selective TGF-β-activated kinase-1 (TAK-1; TAK1) inhibitor (Ki = 2.5 nM; IC50 = 8.25 nM) th at significantly reduced cytokines production in THP-1 human macrophages upon LPS/IFNγ treatment (IC50 = 138 nM/TNF201 nM/IL-6and 234 nM/IL-1β). HS-276 effectively attenuates arthritic-like symptoms in the CIA mouse rheumatoid arthritis (RA) model (10-30 mg/kg/d p.o. or 25 mg/kg/d i.p.).
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