成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

ChemicalBook--->CAS DataBase List--->272105-42-7

272105-42-7

<tt id="ysask"></tt>

  1. <tt id="ysask"></tt>

    1. 272105-42-7 Structure

      272105-42-7 Structure
      IdentificationBack Directory
      [Name]

      Disitertide
      [CAS]

      272105-42-7
      [Synonyms]

      disitertide
      P144 Peptide
      TSLDASIIWAMMQN
      DISITERTIDE, >98%
      P144;P144 PEPTIDE
      Disitertide,P144,P144 Peptide, >98%
      L-Asparagine, L-threonyl-L-seryl-L-leucyl-L-α-aspartyl-L-alanyl-L-seryl-L-isoleucyl-L-isoleucyl-L-tryptophyl-L-alanyl-L-methionyl-L-methionyl-L-glutaminyl-
      L-Threonyl-L-seryl-L-leucyl-L-alpha-aspartyl-L-alanyl-L-seryl-L-isoleucyl-L-isoleucyl-L-tryptophyl-L-alanyl-L-methionyl-L-methionyl-L-glutaminyl-L-asparagine
      [Molecular Formula]

      C68H109N17O22S2
      [MOL File]

      272105-42-7.mol
      [Molecular Weight]

      1580.84
      Chemical PropertiesBack Directory
      [Boiling point ]

      1968.7±65.0 °C(Predicted)
      [density ]

      1.327
      [storage temp. ]

      Store at -20°C
      [solubility ]

      DMSO : ≥ 200 mg/mL (126.52 mM);Water : < 0.1 mg/mL (insoluble)
      [form ]

      Solid
      [pka]

      3.15±0.10(Predicted)
      [color ]

      White to off-white
      [InChI]

      InChI=1/C68H109N17O22S2/c1-12-32(5)53(85-67(105)54(33(6)13-2)84-64(102)48(30-87)82-56(94)35(8)74-61(99)45(27-51(91)92)79-62(100)43(24-31(3)4)78-63(101)47(29-86)83-65(103)52(71)36(9)88)66(104)80-44(25-37-28-72-39-17-15-14-16-38(37)39)60(98)73-34(7)55(93)75-41(20-22-108-10)58(96)77-42(21-23-109-11)59(97)76-40(18-19-49(69)89)57(95)81-46(68(106)107)26-50(70)90/h14-17,28,31-36,40-48,52-54,72,86-88H,12-13,18-27,29-30,71H2,1-11H3,(H2,69,89)(H2,70,90)(H,73,98)(H,74,99)(H,75,93)(H,76,97)(H,77,96)(H,78,101)(H,79,100)(H,80,104)(H,81,95)(H,82,94)(H,83,103)(H,84,102)(H,85,105)(H,91,92)(H,106,107)/t32-,33-,34-,35-,36+,40-,41-,42-,43-,44-,45-,46-,47-,48-,52-,53-,54-/s3
      [InChIKey]

      IUYPEUHIWDMJLM-INGCBPSVNA-N
      [SMILES]

      C(C1=CNC2=CC=CC=C12)[C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@H](C(=O)O)CC(=O)N)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](N)[C@H](O)C |&1:10,14,19,27,35,44,55,56,63,64,71,77,82,90,98,104,106,r|
      Hazard InformationBack Directory
      [Description]

      Disitertide is an inhibitor of TGF-β1. It prevents TGF-β1-dependent inhibition of MV1Lu proliferation in vitro and markedly reduces binding of TGF-β1 to its receptors. Disitertide blocks TGF-β1-dependent stimulation of a reporter gene under the control of human α2(I) collagen promoter. Treatment with Disitertide at low doses causes a significant inhibition of HSC activation and a marked reduction in liver fibrosis in a rat model of chronic exposure to CCl4. A dose as low as 70 μg of the 15-mer peptide Disitertide, given to rats (300 g body weight) on alternate days, decreases fibrogenesis significantly during chronic exposure to CCl4.
      [Biological Activity]

      Disitertide (P144) TFA is a polypeptide inhibitor of transforming growth factor TGFβ1, specifically blocking its interaction with the receptor. Disitertide (P144) is also an inhibitor of PI3K and an inducer of apoptosis.
      [in vitro]

      Disitertide (100 μg/mL) suppresses the protein expression levels of PI3K and p-Akt, and induce the protein expression of Bax in MC3T3-E1 cells.
      Disitertide (TGF-β1 inhibitor) abrogates the MACC1- AS1 expression in GC cells, suggesting that targeting TGFβ signaling pathway may be a potential strategy to inhibit MSC-induced stemness and chemoresistance.
      Disitertide (P144, 10 μg/mL to 200 μg/mL) affects proliferation,

      Western Blot Analysis

      < td class="col2"> Significantly suppressed the protein expression levels of PI3K and p-Akt, and induced the protein expression of Bax in MC3T3-E1 cells compared with the miR-590 group. table>
      Cell Line: Mouse embryo osteoblast precursor MC3T3-E1 cells.
      Concentration:
      Concentration: 100 μg/mL.
      Incubation Time: 4 h.
      Result:
      [in vivo]

      Disitertide (Topical application, 300 μg/mL) may promote scar maturation and clinical improvement of hypertrophic scar morphology features in an “in vivo” model in nude mice after two weeks of treatment.

      Animal Model: Human hypertrophic scars were implanted in 60 nude mice.
      Dosage: 300 μg/mL was added the Lipogel.
      Administration: Topical application daily administered.
      Result: Successful shedding was achieved in 83,3% of the xenografts.
      [storage]

      Store at -20°C
      272105-42-7 suppliers list
      Company Name: BOC Sciences
      Tel: 16314854226; +16314854226 , +16314854226
      Website: https://www.bocsci.com/
      Company Name: Shenzhen Nexconn Pharmatechs Ltd
      Tel: +86-755-89396905 +86-15013857715 , +86-15013857715
      Website: http://www.is0513.com/ShowSupplierProductsList31188/0.htm
      Company Name: CONIER CHEM AND PHARMA LIMITED
      Tel: +8618523575427 , +8618523575427
      Website: http://www.conier.com/
      Company Name: TargetMol Chemicals Inc.
      Tel: +1-781-999-5354 +1-00000000000 , +1-00000000000
      Website: https://www.targetmol.com/
      Company Name: Career Henan Chemica Co
      Tel: +86-0371-86658258 +8613203830695 , +8613203830695
      Website: www.coreychem.com/
      Company Name: Zhejiang J&C Biological Technology Co.,Limited
      Tel: +1-2135480471 +1-2135480471 , +1-2135480471
      Website: https://www.sarms4muscle.com
      Company Name: TargetMol Chemicals Inc.
      Tel:
      Website: www.targetmol.com/
      Company Name: GIHI CHEMICALS CO.,LIMITED
      Tel: +8618058761490 , +8618058761490
      Website: https://www.gihichemicals.com/
      Company Name: Zhejiang Hangyu API Co., Ltd
      Tel: +8617531972939 , +8617531972939
      Website: www.api-made.com
      Company Name: Shanghai Acmec Biochemical Technology Co., Ltd.
      Tel: +undefined18621343501 , +undefined18621343501
      Website: www.acmec.com.cn/
      Company Name: SHANGHAI KEAN TECHNOLOGY CO., LTD.
      Tel: +8613817748580 , +8613817748580
      Website: www.kean-chem.com
      Company Name: Changsha MOL Changes Biotechnology Co., Ltd.
      Tel: +8619375158599 , +8619375158599
      Website: www.molchanges.com
      Company Name: DONBOO AMINO ACID COMPANY
      Tel: +8613063595538 , +8613063595538
      Website: http://www.donboo.com/
      Company Name: MedChemexpress LLC  
      Tel: 021-58955995
      Website: www.medchemexpress.cn
      Company Name: Wuxi Zhongkun Biochemical Technology Co., Ltd.  
      Tel: 0510-85629785 18013409632
      Website: www.reading-chemicals.com
      Company Name: ShangHai Biochempartner Co.,Ltd  
      Tel: 177-54423994 17754423994
      Website: www.biochempartner.com
      Company Name: Beijing Solarbio Science & Tecnology Co., Ltd.  
      Tel: 010-50973130 4009686088
      Website: http://www.solarbio.com
      Company Name: Nanjing Leon Biological Technology Co., Ltd.  
      Tel: 17705183659
      Website: www.njleonbiotech.com
      Tags:272105-42-7 Related Product Information
      39537-23-0 56-53-1 70-47-3 56-85-9