| Identification | Back Directory | [Name]
Apigenin-D5 | [CAS]
263711-74-6 | [Synonyms]
Apigenin-D5
Apigenin-d5 (Major)
Pelargidenon 1449-d5
[3,6,8,35d5]-Apigenin
4',5,7-Trihydroxyflavone-d5
5,7-Dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one-d5 | [Molecular Formula]
C15H5D5O5 | [MDL Number]
MFCD09839941 | [MOL File]
263711-74-6.mol |
| Chemical Properties | Back Directory | [Appearance]
Pale Yellow Crystalline Solid | [Melting point ]
345-350°C | [storage temp. ]
-20°C Freezer | [solubility ]
DMSO (Slightly), Ethanol (Slightly, Heated), Methanol (Slightly) | [form ]
Solid | [color ]
Pale Yellow to Yellow |
| Hazard Information | Back Directory | [Chemical Properties]
Pale Yellow Crystalline Solid | [Uses]
The labelled aglucon of apiin and of apigenin-7-glucoside | [Description]
Apigenin-d5 is an internal standard for the quantificaiton of apigenin by GC- or LC-MS. Apigenin is a flavonoid compound found in many fruits and vegetables that selectively inhibits casein kinase 2 (CK2). Apigenin inhibits CK2 activity in the renal cortex with an IC50 value of 30 μM to improve renal function in a rat model of glomerulonephritis. CK2 inhibition by 20 μM apigenin decreases the degradation of IκBα and down-regulates NF-κB levels in WEHI-231 cells. Apigenin, at 5 μM, is a potent inhibitor of the synthesis of the inflammatory mediators nitric oxide and prostaglandin E2, reducing inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression by 56% and 64%, respectively, in the macrophage cell line J774A.1. |
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Energy Chemical
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guoyungurui
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