| Identification | Back Directory | [Name]
1H-Pyrazol-5-ol, 1-(5-methyl-2-pyridinyl)-3-phenyl- | [CAS]
2579696-76-5 | [Synonyms]
1H-Pyrazol-5-ol, 1-(5-methyl-2-pyridinyl)-3-phenyl- | [Molecular Formula]
C15H13N3O | [MOL File]
2579696-76-5.mol | [Molecular Weight]
251.28 |
| Chemical Properties | Back Directory | [Boiling point ]
480.4±45.0 °C(Predicted) | [density ]
1.22±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 25 mg/mL (99.49 mM; Need ultrasonic) | [form ]
Solid | [pka]
7.15±0.50(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Biological Activity]
COQ7-IN-2 (compound 12) is an inhibitor of COQ7, witn IC50 values of 7.3 μM and 15.4 μM for DMQ10 and UQ10 accumulation, respectively[1].
COQ7-IN-2 (compound 12) has less growth inhibition against human normal culture cells[1].The substantial DMQ10 accumulation occurred in both PANC-1 cells (8.7% by COQ7-IN-2 (compound 12)) and PC3 cells (14.0% by COQ7-IN-2 (compound 12))[1]. | [References]
[1]. Keiko Tsuganezawa, et al. Identification of small molecule inhibitors of human COQ7. Bioorg Med Chem. 2020 Jan 1;28(1):115182. |
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