| Identification | Back Directory | [Name]
PROTAC KRASG12C Degrader-LC-2 | [CAS]
2502156-03-6 | [Synonyms]
LC-2
PROTAC KRASG12C Degrader-LC-2 | [Molecular Formula]
C59H71ClFN11O7S | [MDL Number]
MFCD32857122 | [Molecular Weight]
1132.78 |
| Chemical Properties | Back Directory | [density ]
1.297±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 50 mg/mL (44.14 mM; ultrasonic and warming and heat to 80°C) | [form ]
Solid | [pka]
14.07±0.40(Predicted) | [color ]
Off-white to brown |
| Hazard Information | Back Directory | [Description]
LC-2 is a von Hippel-Lindau-based PROTAC which can degrade endogenous KRAS G12C. It covalently binds KRAS G12C with a MARTX849 warhead and recruits the E3 ligase VHL which degrades the KRAS G12C and suppresses MAPK signaling in homozygous and heterzygous KRAS G12C cell lines. | [storage]
Store at -20°C |
|
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DebyeTec.com Inc.
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DC Chemicals
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Wuhan Topule
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